IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Engineers & Technicians

  Virginie CHAVANT

  Mathilde JOINT

  Adeline PAGE

  Frank RUFFENACH

Technology platforms

Protéomics

On this platform at the intersection of chemistry and biology, many mass spectrometers allow protein and peptides characterization. Researchers resort in this technology to identify over- or under-expressed proteins in patients affected by cancers. Many proteomics applications in clinical biology are currently being developed : autoimmune and genetic disorders, central nervous system and renal pathologies…

• Protéomics Platform official website

• Current projects

• Collaborations

• Prizes/Awards

• News

• Publications

  • Sequestration of DROSHA and DGCR8 by Expanded CGG RNA Repeats Alters MicroRNA Processing in Fragile X-Associated Tremor/Ataxia Syndrome.

    Sellier C, Freyermuth F, Tabet R, Tran T, He F, Ruffenach F, Alunni V, Moine H, Thibault C, Page A, Tassone F, Willemsen R, Disney MD, Hagerman PJ, Todd PK, Charlet-Berguerand N.

    Cell Rep March 28, 2013

  • Mammalian frataxin controls sulfur production and iron entry during de novo Fe4S4 cluster assembly.

    Colin F, Martelli A, Clémancey M, Latour JM, Gambarelli S, Zeppieri L, Birck C, Page A, Puccio H, Ollagnier de Choudens S.

    J Am Chem Soc Jan. 16, 2013

  • An ABC Transporter with Two Periplasmic Binding Proteins Involved in Iron Acquisition in Pseudomonas aeruginosa.

    Brillet K, Ruffenach F, Adams H, Journet L, Gasser V, Hoegy F, Guillon L, Hannauer M, Page A, Schalk IJ.

    ACS Chem Biol Oct. 5, 2012

  • Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through TRKA and sortilin.

    Demont Y, Corbet C, Page A, Ataman-Onal Y, Choquet-Kastylevsky G, Fliniaux I, Le Bourhis X, Toillon RA, Bradshaw RA, Hondermarck H.

    J Biol Chem Jan. 13, 2012

  • Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination

    Jeevan-Raj B.P., Robert I., Heyer V., Page A., Wang J.H., Cammas F., Alt F.W., Losson R., Reina-San-Martin B.

    J Exp Med Aug. 1, 2011

  • Mammalian frataxin: an essential function for cellular viability through an interaction with a preformed ISCU/NFS1/ISD11 iron-sulfur assembly complex.

    Schmucker S, Martelli A, Colin F, Page A, Wattenhofer-Donzé M, Reutenauer L, Puccio H.

    PLoS One Jan. 26, 2011

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