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Prix Alexandre Joannidès 2014 Académie des sciences : Irwin DAVIDSON
At the top: Helical structure of the polyribosome, in blue the 60S subunits facing outwards. At the bottom : Details of protein interactions between the exit site of the mRNA at a ribosome (i), and the entry site of the mRNA on the following ribosome (i + 1). These details show a continuity of the channel that contains the mRNA (red dotted line), from a ribosome to another without forming loops, which allows it to be protected inside.
Nov. 7, 2014
Key elements of protein synthesis, ribosomes are sometimes positioned like beads on a string on the messenger RNA to amplify the effectiveness of translation. While little information was available about the precise structure of this assembly, microscopists and crystallographers of Bruno Klaholz’s team managed to determine its precise configuration in 3 dimensions, providing new information on the mechanisms of translation. These results are published November 7th in the journal Nature Communications.
According to the location of damaged genes in the nucleus, the cell is able to trigger different and adapted repair mechanisms.
Nov. 3, 2014
The double-strand DNA breaks are particularly dangerous. The research team of Evi Soutoglou at IGBMC has just discovered that the choice of natural repair mechanisms of the cell, in response to this type of injury, depends on the location of genes in the nucleus. These results are published on the 3rd of November in the journal Genes & Development.
Nov. 24, 2014
Thomson Reuters, the world leader in intelligent systems for businesses and professionals, released on June 18, 2014 the list of the most influential scientists of the world. Based on a bibliometric analysis of articles published between 2002 and 2012 in 21 scientific fields and indexed in the Web of Science (database that collects much of the world's scientific publications), the group has published a list of scientists whose work is most frequently cited by their parties. Among the 3,200 researchers listed are two IGBMC researchers : Pierre Chambon and Hinrich Gronemeyer. Congratulations to them!