4 research departments
750 employees
45 nationalities
55 research teams
16 ERC laureates
260 publications per year
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Fondation universite de Strasbourg
Thursday, June 2nd 2016 - 2 p.m.
Dr Radhika Subramanian

Cellular LEGO: constructing cellular structures from protein building blocks

Thursday, June 2nd 2016 - 11 a.m.
Pr Tomas Lindahl

The Intrinsic fragility of DNA

Friday, June 17th 2016 - 11 a.m.
Pr Dinshaw J. Patel

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Phd Programme

Production of unstable proteins through the formation of stable core complexes

To assemble stable functional complexes, various partners (multi-domains proteins (X-Y-Z) connected by unstructured linkers (blue lines) allowing high inter domain flexibility (double arrow), single domain proteins (A, B), nucleic acids (DNA or RNA), small molecules (yellow disks)) are necessary.

March 29, 2016

The team of Marc Ruff works on chromatin stability and DNA mobility. Scientists have recently developed a methodology that enables the production of stable complexes for their structural and functional studies. These results were published in the journal Nature Communications on March 17, 2016.

 

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Towards a better understanding of heart disease at the root of myotonic dystrophy

Alternative splicing model of the cardiac sodium channel (SCN5A) in a myotonic dystrophy.

April 11, 2016

The team of Nicolas Charlet-Berguerand (CNRS, Inserm and University of Strasbourg) part of an international collaboration (France, Germany, USA and Japan) lift the veil on the molecular mechanisms behind heart defects in the genetic disease, myotonic dystrophy. An illness that affects a person over 8 000. This new study published in Nature Communications on April 11 2016 could help find a treatment.

 

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The formation of heart valves finally determined

Picture of the endocardial cells of zebrafish heart after photoconversion(1) of the ventricle of the heart. The ventricle which is photoconverted appears in mauve while the atrium, which is not photoconverted, appears in green. This approach allowed the researchers to address cellular mechanisms associated with the formation of the heart valves.

 

(1) Photoconversion: the conversion of a substance from one form to another by using the energy supplied by light.

May 25, 2016

The team of Julien Vermot is working on the mechanisms that regulate the formation of the heart valves. The researchers were able to show how heart valves are formed in response to changes in the extracellular matrix that is mediated by mechanical forces exerted by the heart muscle contractions. The researchers hope this discovery will help to better understand how to grow the heart valves in vitro. These results have been published on May 25, 2016 in the journal Nature Communications.

 

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