4 research departments
750 employees
45 nationalities
49 research teams
11 ERC laureates
250 publications per year
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Mon, November 24th - Wed, November 26th 2014

New strategies for macromolecular complexes analysis

Wed, November 26th - Fri, November 28th 2014

New strategies for macromolecular complexes analysis

Thu, December 4th - Fri, December 5th 2014

DEVELOPMENT & STEM CELLS 2014 SYMPOSIUM

Mon, January 19th - Tue, January 20th 2015

Chemical Complexity & Biology

Prix Alexandre Joannidès 2014 Académie des sciences : Irwin DAVIDSON


Focus on helical polyribosomes

At the top: Helical structure of the polyribosome, in blue the 60S subunits facing outwards. At the bottom : Details of protein interactions between the exit site of the mRNA at a ribosome (i), and the entry site of the mRNA on the following ribosome (i + 1). These details show a continuity of the channel that contains the mRNA (red dotted line), from a ribosome to another without forming loops, which allows it to be protected inside.

Nov. 7, 2014

Key elements of protein synthesis, ribosomes are sometimes positioned like beads on a string on the messenger RNA to amplify the effectiveness of translation. While little information was available about the precise structure of this assembly, microscopists and crystallographers of Bruno Klaholz’s team managed to determine its precise configuration in 3 dimensions, providing new information on the mechanisms of translation. These results are published November 7th in the journal Nature Communications.

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SAGA: an underestimated role in the transcription of our genes

While the amount of total mRNA seemed little affected when SAGA is inhibited (bottom), the net production of new mRNA in the mutants is drastically reduced on all the genes (top).

Sept. 15, 2014

A study coordinated by Didier Devys in Làszlò Tora’s team at the IGBMC highlights the crucial role of the SAGA coactivator complex in the transcription of our genes, largely underestimated so far. Indeed they proved that it has a role throughout the entire transcribed genome and is essential for proper functioning of the RNA polymerase II. These results are published on September 15th in the journal Genes & Development.

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IGBMC call for group leader positions in Functional Genomics & Cancer

Oct. 1, 2014

The Functional Genomics and Cancer (FGC) Department of IGBMC is recruiting new group leaders with support from the Laboratory of Excellence (LabEx) initiative.

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A novel role for TAF4 in post-natal hepatocyte maturation

Upper panel: Section through a normal liver. The cell membranes are well delimited (in green) and normal bile ducts (BD) are formed.
Lower panel: Section through a liver lacking TAF4. The cell membranes are less well delimited (in green), and the bile ducts are defective (dBDs) and do not form a proper lumen to drain the bile from the liver.

Oct. 3, 2014

The group of Irwin Davidson have discovered a novel role for the TAF4 protein in hepatocyte maturation opening the way to understanding its eventual role in diabetes. The results are published by Alpern et al., on 3 October in eLife.

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DNA damage: repair adapted in space

According to the location of damaged genes in the nucleus, the cell is able to trigger different and adapted repair mechanisms.

Nov. 3, 2014

The double-strand DNA breaks are particularly dangerous. The research team of Evi Soutoglou at IGBMC has just discovered that the choice of natural repair mechanisms of the cell, in response to this type of injury, depends on the location of genes in the nucleus. These results are published on the 3rd of November in the journal Genes & Development.

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Université de Strasbourg
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