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While being dispensable for somatic hypermutation (SHM), the DNA repair factor Parp3 plays a dual role during immunoglobulin class switch recombination (CSR). Parp3 promotes the repair of double stranded DNA breaks (DSBs) induced by AID through the non homologous end joining (NHEJ) pathway and protects the immunoglobulin heavy (IgH) chain locus from sustained AID-induced DNA damage by promoting the eviction of the mutagenic enzymatic activity of AID from chromatin.
June 15, 2015
The team of Bernardo Reina-San-Martin at IGBMC revealed new control mechanisms operating during antibody diversification. They have shown that the DNA repair factor Parp3 plays a dual role during immunoglobulin class switch recombination (CSR).
Parp3 promotes the repair of physiological DNA double strand breaks inflicted at the immunoglobulin heavy chain (IgH) locus and it protects the locus against sustained DNA damage.
This work provides novel insight in the mechanisms underlying the efficient generation of protective antibodies and the maintenance of genomic stability.
These results are published in Plos Genetics May 22nd 2015.