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SAGA: an underestimated role in the transcription of our genes

While the amount of total mRNA seemed little affected when SAGA is inhibited (bottom), the net production of new mRNA in the mutants is drastically reduced on all the genes (top).

Sept. 15, 2014

A study coordinated by Didier Devys in Làszlò Tora’s team at the IGBMC highlights the crucial role of the SAGA coactivator complex in the transcription of our genes, largely underestimated so far. Indeed they proved that it has a role throughout the entire transcribed genome and is essential for proper functioning of the RNA polymerase II. These results are published on September 15th in the journal Genes & Development.

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Towards a better understanding of DNA repair and related diseases

The TTDA protein is fused to the protein LacR and to a fluorescent protein (GFP) in order to form a chimeric protein, able to recognize LacO sequences (green spots). When TTDA is mutated (right), the protein is fixed on the genome (top right) but XPA (red) is not recruited downstream (no spot in the bottom right).

Aug. 25, 2014

The research team of Frédéric Coin has just highlighted new mechanisms of the nucleotide excision DNA repair (NER) pathway, allowing them to take a new step in understanding trichothyodystrophy, a genetic disease that alters this process. Their findings are published on August 25th in the Journal of Cell Biology.

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Interplay of symmetry and asymmetry in a nuclear receptor

3D structure of the USP/EcR complex, bound to DNA (in blue) on the 5' end of palindromic response elements.

June 19, 2014

Recently installed in the new Centre for Integrative Biology of the IGBMC, the researchers of Bruno Klaholz’s team got interested in the nuclear receptor of ecdysone, an insect hormone, revealing its structure including the hormone and the DNA binding regions. These results, published on June 19th in the journal Nature Communications, highlight an unexpected asymmetry and provide new insights into the overall functioning of steroid receptors.

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The keys to the transdifferentiation

The role of various factors can be described as the different layers in an onion. While TF are at the heart of the mechanism providing control and basal efficiency of the process, the EF involved act as additive protective layers, which insulate the process against variations induced by the environment.

Aug. 15, 2014

Will we soon be able to replace our aging or injured tissues? Can we envision new approaches in regenerative medicine through the efficient reprogramming of the cell identity? During organogenesis, cells acquire and maintain specialized characteristics until their death. An uncontrolled loss of these features can result in cancer. However, a particularly rare and interesting phenomenon has been discovered recently: some cells do lose their identity to acquire a new one. This mechanism called "transdifferentiation" thrills scientists, with its many potential applications in regenerative medicine... The team of Sophie Jarriault has just unravelled the key factors that determine the efficiency and robustness of this conversion mechanism in the worm C. elegans. These results are published on August 15th 2014 in the journal Science.

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