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Prix Alexandre Joannidès 2014 Académie des sciences : Irwin DAVIDSON
Upper panel: Section through a normal liver. The cell membranes are well delimited (in green) and normal bile ducts (BD) are formed.
Lower panel: Section through a liver lacking TAF4. The cell membranes are less well delimited (in green), and the bile ducts are defective (dBDs) and do not form a proper lumen to drain the bile from the liver.
Oct. 3, 2014
The group of Irwin Davidson have discovered a novel role for the TAF4 protein in hepatocyte maturation opening the way to understanding its eventual role in diabetes. The results are published by Alpern et al., on 3 October in eLife.
Visualization of inhibitors binding sites on the two subunits of the eukaryotic ribosome. There are four main binding sites: the binding area of the messenger RNA, the decoding center, the E-site binding site of transfer RNA and the peptidyl transferase center.
Sept. 10, 2014
Protein biosynthesis is an essential for biological process that takes place in all living cells and is performed by the ribosomes. Understanding the highly complex structure of the ribosomes and their blocking agents is a challenge that have tried to meet for several years the teams of Marat Yusupov and Gulnara Yusupova at IGBMC. In their latest work published on September 10th in Nature, they reveal the high resolution structures of the eukaryotic ribosome, in complex with no less than 16 inhibitors, providing critical new data for the development of new drugs.
3D structure of the USP/EcR complex, bound to DNA (in blue) on the 5' end of palindromic response elements.
June 19, 2014
Recently installed in the new Centre for Integrative Biology of the IGBMC, the researchers of Bruno Klaholz’s team got interested in the nuclear receptor of ecdysone, an insect hormone, revealing its structure including the hormone and the DNA binding regions. These results, published on June 19th in the journal Nature Communications, highlight an unexpected asymmetry and provide new insights into the overall functioning of steroid receptors.
While the amount of total mRNA seemed little affected when SAGA is inhibited (bottom), the net production of new mRNA in the mutants is drastically reduced on all the genes (top).
Sept. 15, 2014
A study coordinated by Didier Devys in Làszlò Tora’s team at the IGBMC highlights the crucial role of the SAGA coactivator complex in the transcription of our genes, largely underestimated so far. Indeed they proved that it has a role throughout the entire transcribed genome and is essential for proper functioning of the RNA polymerase II. These results are published on September 15th in the journal Genes & Development.
Oct. 1, 2014