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Prix René et Andrée Duquesne 2015 Ligue contre le cancer : Hinrich GRONEMEYER Médaille de bronze 2015 CNRS : Evi SOUTOGLOU Médaille de cristal 2015 CNRS : Philippe ANDRE
Scheme of in vitro experiments showing that the movement of the cells can be directed through a locally repeated asymmetry (here an asymmetry of the substrate)
Nov. 24, 2015
Directed migration of cells in the body is often explained by long-range physical or chemical gradients. However, in collaboration with Matthieu Piel’s team at the Institut Curie and Raphaël Voituriez, a researcher in theoretical physics at UPMC, Daniel Riveline's team has shown that other types of more local signals can influence cell migration. Their work is published on November 24th in the Journal Trends in Cell Biology.
The BIN1 gene (encoding for amphiphysin) is regulating the positioning of the nucleus through several proteins related to the cytoskeleton: amphiphysin binds to nesprin, an actin interactor, and directly to actin filaments. Amphiphysin also partners with CLIP170, a microtubule-associated protein.
Oct. 26, 2015
The place of the nucleus is important for the organization of cells and tissue development. This positioning is altered in many diseases such as centronuclear myopathies. In a study published on October 26th in Developmental Cell, the teams of Jocelyn Laporte and Michel Labouesse, in collaboration with those of Edgar Gomes in Lisbon and Vincent Gache in Lyon, have just identified a key player in the nucleus positioning mechanism: the amphiphysin.
Schematic overview of TARDIS and its modular workflows.
Oct. 29, 2015
During the last years, RNA sequencing has become a widely used tool to study RNA expression. However, a cost-effective and universal protocol capable of dealing with any source of input RNA was not available till date. In a study coordinated by Maximiliano Portal and Hinrich Gronemeyer at the IGBMC, the scientists have developed a method for RNA-sequencing library preparation that is capable of querying the entire transcriptome of any organism, regardless of RNA length, function, the presence or absence of poly-A or biogenesis mechanism. Called TARDIS (for Targeted Directional Sequencing RNA), this protocol was published on October 29th in the journal Nature Protocols.
From left to right: Marat Yusupov, Gulnara Yusupova and Jean-Paul Renaud
Nov. 5, 2015
One year after the publication in Nature of 16 crystallographic structures of the yeast 80S ribosome in complex with various inhibitors by the teams of Marat Yusupov and Gulnara Yusupova, the RiboStruct start-up project led by Jean-Paul Renaud has now materialized.
Heatmaps showing the dynamic regulation of the epigenetic mark H3K27me3 during T cell differentiation (blue and yellow: low and high H3K27me3 levels), and the mRNA expression of the corresponding genes (green and red: low and high expression levels) in WT and Ikaros-deficient mice.
Nov. 9, 2015
The differentiation of different types of blood cells is dependent on complex genetic and epigenetic programs. Attila Oravecz in the team of Susan Chan and Philippe Kastner uncovered a novel epigenetic regulatory mechanism in the early stages of the differentiation of T lympocytes controlled by the Ikaros transcription factor. Published on November 9th in Nature Communications, this study highlights the repressive role of the latter on many specific genes of hematopoietic stem cells. Ikaros recruits Polycomb complex PRC2 to deposit repressive epigenetic marks. This work highlights a new epigenetic repression mechanism that could explain the tumor suppressor function of Ikaros in leukemia.