4 research departments
750 employees
45 nationalities
49 research teams
11 ERC laureates
250 publications per year
24000 m² lab area

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Fondation universite de Strasbourg
Monday, August 17th 2015 - 11 a.m.
Dr Farrah El-Saafin

Investigating the Molecular and Cellular function of TAF8

Friday, August 28th 2015 - 11 a.m.
Dr Nabil Djouder

Growth factors, Nutrients and Cancer

Wednesday, September 2nd 2015 - 4 p.m.
Dr Céline Galvagnon

New insights into the mechanism of alpha-synuclein amyloid formation

Monday, September 7th 2015 - 2 p.m.
Dr Gaëlle Legube

DNA Double Strand Break repair in the context of chromatin

Médaille de bronze 2015 CNRS : Evi SOUTOGLOU Médaille de cristal 2015 CNRS : Philippe ANDRE


IGBMC call for group leaders positions in Bioinformatics

June 2, 2015



IGBMC is recruiting up to 4 new group leaders in Bioinformatics with support from the Laboratory of Excellence (LabEx INRT) initiative.

  • Application deadline: 3 August 2015.

  • Interviews: 24 & 25 September 2015.

 New groups are expected to start in 2016.


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Imprimer Envoyer

Standardized methods for an international initiative to decipher the gene functions

July 27, 2015

One of the major current challenges of biology is to assign one or several function(s) to each of the genes in the genome. To achieve these functional annotations, 4 European centers have embarked on large-scale analyzes (phenotyping) on mouse genes. After setting up standardized, reproducible and reliable tests, they now produce the results of the analysis of 449 genes with functional annotation for 83% of them. These results are published in the journal Nature Genetics.


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A dual role for Parp3 during immunoglobulin class switch recombination

© IGBMC

 

While being dispensable for somatic hypermutation (SHM), the DNA repair factor Parp3 plays a dual role during immunoglobulin class switch recombination (CSR). Parp3 promotes the repair of double stranded DNA breaks (DSBs) induced by AID through the non homologous end joining (NHEJ) pathway and protects the immunoglobulin heavy (IgH) chain locus from sustained AID-induced DNA damage by promoting the eviction of the mutagenic enzymatic activity of AID from chromatin.

June 15, 2015

The team of Bernardo Reina-San-Martin at IGBMC revealed new control mechanisms operating during antibody diversification. They have shown that the DNA repair factor Parp3 plays a dual role during immunoglobulin class switch recombination (CSR).

Parp3 promotes the repair of physiological DNA double strand breaks inflicted at the immunoglobulin heavy chain (IgH) locus and it protects the locus against sustained DNA damage.

This work provides novel insight in the mechanisms underlying the efficient generation of protective antibodies and the maintenance of genomic stability.


These results are published in Plos Genetics May 22nd 2015.


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From pluripotency to totipotency

Aug. 3, 2015

While it is already possible to obtain in vitro pluripotent cells (ie, cells capable of generating all tissues of an embryo) from any cell type, researchers from Maria-Elena Torres-Padilla’s team have pushed the limits of science even further. They managed to obtain totipotent cells with the same characteristics as those of the earliest embryonic stages and with even more interesting properties. Obtained in collaboration with Juanma Vaquerizas from the Max Planck Institute for Molecular Biomedicine (Münster, Germany), these results are published on 3rd of August in the journal Nature Structural & Molecular Biology.



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Université de Strasbourg
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IGBMC - CNRS UMR 7104 - Inserm U 964
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