The Team
  • Researchers

    Fabien ALPY

    Nassim DALI YOUCEF

    Catherine-Laure TOMASETTO

  • Phd Students

    Thien-Nga CHAMARAUX-TRAN

    Thomas DI MATTIA

    Bing TAN

    Léa WILHELM

  • Engineers & Technicians

    Corinne WENDLING

  • Master

    Amélie JAULIN

Functional genomics and cancer

Molecular and cellular biology of breast cancer

The natural history of breast cancer involves progression through clinical stages starting with abnormal epithelial proliferation, progressing into in situ and invasive carcinomas, concluding eventually in metastatic disease. The progression from in situ to invasive carcinoma is a critical step in terms of prognosis and relies on cancer and normal cells present in the tumor. In this context, MMP11 identification as a secreted mesenchymal factor associated with invasive breast cancer was a pioneer finding in the field of invasion. Using a variety of cellular and mouse models of tumorigenesis, MMP11 expression by stromal cells was shown to be crucial in the invasive process. Moreover, prognostic studies indicated its association with a poor patient outcome. Indeed, the Oncotype DX that predict breast cancer relapse includes MMP11 dosage. Our first objective is to decipher the role of MMP11 during tumor progression.
Breast cancer is a heterogeneous disease that is currently classified into 3 main classes: luminal (estrogen receptor (ER) and progesterone receptor (PR) positive), HER2 (a member of the epidermal growth factor (EGF) receptor family) positive and basal-like, which is primarily PR, ER and HER2 negative (ie, triple negative). By comparing benign and malignant breast biopsies, we have identified several genes including pS2/ TFF1 expressed in luminal tumors and TRAF4, MLN51 and STARD3 which are specifically expressed in HER2 tumors. All of these genes are expressed by cancer cells and our objective is focused on the functional characterization of the respective proteins.

Imprimer Envoyer

Université de Strasbourg
INSERM
CNRS

IGBMC - CNRS UMR 7104 - Inserm U 964
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr