The Team
  • Researchers

    Irwin DAVIDSON

    Igor MARTIANOV

    Gabrielle MENGUS

  • Post-Doctoral Fellows

    Marie ENNEN

    Anas FADLOUN

    Shilpy JOSHI

    Patrick LAURETTE

  • Phd Students

    Sébastien COASSOLO

    Thomas KLEIBER

    Bujamin VOKSHI

  • Engineers & Technicians

    Youenn DAVIDSON

    Isabelle MICHEL

  • Trainee

    Zakaria MOSTEFAI

Functional genomics and cancer

Structure and function of the general transcription factor TFIID

The main focus of our work over the last several years has been to understand the role of TFIID subunits such as TAF4 or paralogues such as TAF4b, TRF2 or TAF7L in gene expression. The study of TAF4 function in cells derived from genetically modified mice in vitro and tissue-specific knockouts in vivo revealed novel facets of its function as a regulator of multiple signaling pathways and cell proliferation, as well as a tumor suppressor. The study of TAF4 as a co-activator for the retinoic acid receptors (RARs), allowed us to decipher the molecular mechanism of cross-talk between the RA and TGF-beta signaling pathways that promotes cell proliferation. We completed this cycle of experiments by using ChIP-chip to identify RAR occupied loci and to target genes revealing the importance of cell-specific binding site occupancy in determining the biological response to RA.
More recently, we were responsible for setting up high throughput sequencing techniques at the IGBMC. The implementation of these technologies has profoundly altered our experimental Programme over the last few years al- lowing us to ask different sets of questions. We have begun to use these techniques to understand the role of various transcription factors in developmental and pathological processes.

Imprimer Envoyer

Université de Strasbourg
INSERM
CNRS

IGBMC - CNRS UMR 7104 - Inserm U 964
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr