The Team
  • Researchers

    Susan CHAN

    Céline CHARVET

    Beate HEIZMANN

    Philippe KASTNER


  • Phd Students

    Giovanni COVA

    Gaëtan MAURER

  • Engineers & Technicians

    Patricia MARCHAL

Functional genomics and cancer

Hematopoiesis and leukemogenesis in the mouse

Hematopoiesis is characterized by the development of hematopoietic stem cells into pluripotent progenitor cells and finally into mature blood cells. This orderly and continuous process involves self-renewal, cell fate choice, differentiation and proliferation. Transcription factors are responsible for coordinating these processes but their expression must be tightly regulated to prevent hematological malignancies. In this context, we are interested in the following questions.
How do transcription factors control hematopoiesis ?
How do alterations in their function contribute to leukemogenesis ?
Our current studies focus on the Ikaros family of transcription factors, which act mainly as transcriptional repressors through association with chromatin remodeling complexes. Ikaros (Ikzf1) is a zinc finger protein expressed by all hematopoietic cells. Ikaros is crucial for lymphocyte differentiation and homeostasis and also functions as a tumor suppressor in T and B cells. Furthermore, loss of Ikaros has been detected in human T- and B-cell acute lymphoblastic leukemias (ALLs). The molecular mechanisms responsible for these activities remain unclear.

Imprimer Envoyer

Université de Strasbourg

IGBMC - CNRS UMR 7104 - Inserm U 964
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 /