Key figures

16 research teams
42 researchers
32 post-doctoral fellows
39 PhD students
34 engineers & technicians
10 master students

Quick Links

Functional genomics and cancer

Expression and maintenance of the genetic information

The fundamental mechanisms regulating gene expression have been one of the major research areas of the IGBMC for more than 30 years. Since the initial purification and characterization of RNA polymerase II by Pierre Chambon and colleagues, a consistent theme has been the identification and the study of the machinery required for basal and regulated transcription. The isolation of major transcription factors such as TFIIH or TFIID as well as the study of nuclear receptors, transcription factors whose activity is regulated by a diverse set of hormones and metabolites, proved a major advance in understanding the close link between transcription, genome stability and human disease such as cancer. Currently, the Department « Functional Genomics and Cancer » has incorporated the study of epigenetics and chromatin dynamics, RNA metabolism, as well as high-throughput genomics and last generation proteomics technologies as it pursues its quest to understand the regulation of gene expression in normal and pathological situations.

Add all department events to your calendar ics icon

Imprimer Envoyer

Université de Strasbourg

IGBMC - CNRS UMR 7104 - Inserm U 964
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 /