The Team
  • Researchers


    Gérard GRADWOHL

  • Post-Doctoral Fellows

    Sabitri GHIMIRE

  • Phd Students

    Colette GIETHLEN

    Julia GRANS

  • Engineers & Technicians

    Céline LAPP

    Aline MEUNIER

  • Master

    Kateryna LYPOVETSKA

Development and stem cells

Differentiation and physiopathology of endocrine cells in the pancreas and intestine

Future strategies for cell replacement therapies and regenerative medicine strongly depend on our knowledge of the detailed mechanisms that control the differentiation of multipotent stem cells into highly specialized cells. Along these lines of research, our goal is to understand how pancreatic and intestinal endocrine cells are generated from endodermal stem/progenitor cells during embryogenesis towards adult life. Pancreatic endocrine cells are clustered in islets within the exocrine tissue and include insulin- secreting beta cells that control glucose homeostasis and become destroyed in Type-1 diabetes. Intestinal endocrine cells, also called enteroendocrine (EE) cells, are closely related endocrine cells, found within the intestinal epithelium.  EE-cells secrete a variety of hormones, controlling different aspects of digestion, including the glucoincretins GLP-1 and GIP which promote pancreatic insulin secretion. Particularly, we focus on the role of transcription factors and signals in the control of cell fate choices and the acquisition of the generic and specific properties of islet and enteroendocrine cell during organogenesis. We hope that our studies will contribute to the development of a cell based therapy in diabetes, as well as to understand the mechanisms underlying the pathophysiology of islet and enteroendocrine hormone failure in human.

Imprimer Envoyer

Université de Strasbourg

IGBMC - CNRS UMR 7104 - Inserm U 964
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 /