The Team
  • Researchers

    Anne-Cécile REYMANN

  • PhD Students

    Grégoire MATHONNET

  • Engineers & Technicians

    Delphine SUHNER

Development and stem cells

Actin dynamics and biomechanics of the early embryo

 

During embryonic development, cell architectures equilibrate and remodel perpetually to enable proper cellular identity and correct cell positioning. The cell cortex, a submicron network under the cell membrane consisting mostly of actin filaments and myosin molecular motors, is the active material that controls cell architecture. This actin cortex thus drives cell shape changes, force sensing and force production by constant assembly-disassembly processes using a wide palette of molecular building blocks.

 

We study the assembly dynamics and biophysical properties of the actin cortex in early C. elegans development. We aim to reveal how these properties are regulated and change over time to control early morphogenesis processes during the first few divisions of the C. elegans embryo. This work is interdisciplinary at the interface of biochemistry, cell biology and physics.

Imprimer Envoyer

Université de Strasbourg
INSERM
CNRS

IGBMC - CNRS UMR 7104 - Inserm U 1258
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr