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SAGA: an underestimated role in the transcription of our genes

While the amount of total mRNA seemed little affected when SAGA is inhibited (bottom), the net production of new mRNA in the mutants is drastically reduced on all the genes (top).

Sept. 15, 2014

A study coordinated by Didier Devys in Làszlò Tora’s team at the IGBMC highlights the crucial role of the SAGA coactivator complex in the transcription of our genes, largely underestimated so far. Indeed they proved that it has a role throughout the entire transcribed genome and is essential for proper functioning of the RNA polymerase II. These results are published on September 15th in the journal Genes & Development.

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Towards a better understanding of DNA repair and related diseases

The TTDA protein is fused to the protein LacR and to a fluorescent protein (GFP) in order to form a chimeric protein, able to recognize LacO sequences (green spots). When TTDA is mutated (right), the protein is fixed on the genome (top right) but XPA (red) is not recruited downstream (no spot in the bottom right).

Aug. 25, 2014

The research team of Frédéric Coin has just highlighted new mechanisms of the nucleotide excision DNA repair (NER) pathway, allowing them to take a new step in understanding trichothyodystrophy, a genetic disease that alters this process. Their findings are published on August 25th in the Journal of Cell Biology.

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The keys to the transdifferentiation

The role of various factors can be described as the different layers in an onion. While TF are at the heart of the mechanism providing control and basal efficiency of the process, the EF involved act as additive protective layers, which insulate the process against variations induced by the environment.

Aug. 15, 2014

Will we soon be able to replace our aging or injured tissues? Can we envision new approaches in regenerative medicine through the efficient reprogramming of the cell identity? During organogenesis, cells acquire and maintain specialized characteristics until their death. An uncontrolled loss of these features can result in cancer. However, a particularly rare and interesting phenomenon has been discovered recently: some cells do lose their identity to acquire a new one. This mechanism called "transdifferentiation" thrills scientists, with its many potential applications in regenerative medicine... The team of Sophie Jarriault has just unravelled the key factors that determine the efficiency and robustness of this conversion mechanism in the worm C. elegans. These results are published on August 15th 2014 in the journal Science.

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Neural stem cells: a finely controlled destiny

The differentiation of the neural stem cell in glial cell is dependent on both Gcm and Repo protein levels, which jointly act in a first rising phase. Once Repo reaches a threshold value, it acts by inhibiting Gcm, causing a drastic drop of the protein level in the cell and the finalization of the glial cell differentiation.

July 28, 2014

How is the formation of brain cells controlled ? The team of Angela Giangrande has just highlighted the molecular mechanisms of the fate of neural stem cells, at the origin of all cells constituting our brain. Their results are published on the 28th of July in the journal Nature communications.

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