4 research departments
750 employees
45 nationalities
55 research teams
16 ERC laureates
260 publications per year
24000 m² lab area

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Discovery of a new pathogenic mechanism in Amyotrophic lateral sclerosis

The loss of C9ORF72 partially alters macroautophagy but doesn’t cause neuronal cell death. In contrast, decreasing expression of C9ORF72 increases the aggregation and toxicity of Ataxin-2 containing polyglutamine repeats. The number of polyglutamine in ATXN2 gene is a genetic modifier known in ALS.

April 21, 2016

The team of Nicolas Charlet-Berguerand at the IGBMC in collaboration with the team of Edor Kabashi at the Institute for Brain and Spinal Cord Disorders (ICM) in Paris have set light a new pathogenic mechanism in Amyotrophic lateral sclerosis. These results were published in the journal EMBO, April 21th 2016.



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Production of unstable proteins through the formation of stable core complexes

To assemble stable functional complexes, various partners (multi-domains proteins (X-Y-Z) connected by unstructured linkers (blue lines) allowing high inter domain flexibility (double arrow), single domain proteins (A, B), nucleic acids (DNA or RNA), small molecules (yellow disks)) are necessary.

March 29, 2016

The team of Marc Ruff works on chromatin stability and DNA mobility. Scientists have recently developed a methodology that enables the production of stable complexes for their structural and functional studies. These results were published in the journal Nature Communications on March 17, 2016.

 

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IGBMC Researchers once again distinguished by the European Research Council

April 25, 2016

Since 2007, the European Research Council (ERC) finances every years projects carried out by talented researchers throughout Europe. The choice of recipients is very selective for these prestigious funding and very few French researchers access these prestigious awards. Since 2013, no less than 7 researchers at the IGBMC, a joint research unit of CNRS/Inserm/University of Strasbourg who have received ERC grant.



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A new team at the IGBMC

A new team at the IGBMC

April 12, 2016

Last January, the IGBMC welcomed a new team leader: Gilles TRAVE and his coworkers Danièle ALTSCHUH, Yves NOMINE, and Irina Paula SUAREZ. We are all happy to receive this new team who will join the Department of Integrative Structural Biology. Its research theme will be: Viral Oncoproteins and Domain-motif networks.

 

To learn more about this team you can click on this link http://www.igbmc.fr/trave/. There is also a scientific news describing recent results of this team available by clicking on the button "More information".

 

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Towards a better understanding of heart disease at the root of myotonic dystrophy

Alternative splicing model of the cardiac sodium channel (SCN5A) in a myotonic dystrophy.

April 11, 2016

The team of Nicolas Charlet-Berguerand (CNRS, Inserm and University of Strasbourg) part of an international collaboration (France, Germany, USA and Japan) lift the veil on the molecular mechanisms behind heart defects in the genetic disease, myotonic dystrophy. An illness that affects a person over 8 000. This new study published in Nature Communications on April 11 2016 could help find a treatment.

 

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Université de Strasbourg
INSERM
CNRS

IGBMC - CNRS UMR 7104 - Inserm U 964
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