Pathogenesis of inflammatory diseases
Pathogenesis of inflammatory diseases
The conceptual focus of inflammatory diseases has shifted to epithelium (e.g. skin, airway and gut), which besides provides a physical barrier, also plays active roles in initiating and maintaining the inflammatory responses. Our studies from the last years have established the key role of epithelium-derived cytokine thymic stromal lymphopoietin (TSLP) in pathogenesis of atopic diseases including atopic dermatitis and asthma. Moreover, TSLP also emerges as a critical player widely implicated in various inflammatory pathologies, such as inflammatory bowel diseases, autoimmunity and cancer. The goals of our research are to investigate how TSLP expression is dysregulated in pathogenic contexts, to decode the complex cellular and molecular networks driven by TSLP in the inflammatory response, and to explore how such networks are implicated in pathogenesis of a variety of inflammatory diseases notably atopic diseases and cancer. To achieve these goals, we utilize integrated approaches of mouse genetic, pathophysiology-relevant mouse models, cellular and molecular biology, as well as systems biology. Based on the acquired knowledge, we also conduct collaborative studies with clinical researchers, with the ultimate goal to develop new biomarkers and therapeutic/prevention strategies for human inflammatory diseases.
Members
Researchers
PhD students
Engineers
Occasionnal collaborators
Former members
Beatriz Germán Falcón (PhD thesis -2020)
Pierre Marschall (PhD thesis -2019)
Wenjin Yao (PhD thesis -2018)
Carole El Hachem (PhD thesis -2017)
Ruicheng Wei (PhD thesis -2016)
Jiagui Li (PhD thesis -2014)
Juan Manuel Leyva Castillo (PhD thesis -2012)
Zhikun Zhang (PhD thesis – 2008)
Postdoc
Grace Ada Da Silva (2020)
John Lindler (2013-2014)
Simone Reipschlager (2014-2015)
Hua Jiang (2008-2011)
ITA
Pierre Hener (2002-2019)
Jordane Heller (2017-2019)
Cecile Hugel (2019)
Julie Demenez (2019-2020)
Master 2
Marine Guivarch (2021)
Clara Menoret (2020)
Antoine Braud (2020)
Pierre Meyer (2019)
Justine Segaud (2018)
Pierre Marschall (2015)
Current projects
- Cellular and molecular networks driven by TSLP in skin immunity
- TSLP-driven immune networks in the pathogenesis of atopic dermatitis and the atopic march
- Regulation of inflammatory microenvironment associated with cutaneous melanoma
News
Allergies: preventing the progression from atopic dermatitis to asthma
In a study published in the journal Nature Communications, scientists highlight the importance of two proteins in the progression from atopic…
Read more
Awards and recognitions
- Prize for EFIS-EJI Registration Grant in World Immune Regulation Meeting XV (2021) - Justine Segaud
- PhD thesis prize of Foundation of the University of Strasbourg (2021) – Beatriz Germán Falcón
- PhD thesis prize of Strasbourg Biology Society (2021) – Beatriz Germán Falcón
- Prix Charles Grupper - LEO Pharma (2019) – Beatriz Germán Falcón for the publication “Disrupting IL-36 and IL-23/IL-17 loop underlies the efficacy of calcipotriol and corticosteroid therapy for psoriasis. German, B.*, Wei, R.*, Hener, P., Martins, C, Ye, T., Gottwick, C, Yang, J, Seneschal, J., Boniface, K and Li, M. JCI Insight doi: 10.1172/jci.insight.123390.”
- Poster Prize (2018) in “15th International Symposium on Dendritic Cells” (Aachen, Germany) – Pierre Marschall
- IdEx Excellence Prize for "Poster Walk" (2018) in “ 35e Congrès Annuel de la Recherche Dermatologique” (Bordeaux, France) – Wenjin Yao
- Poster Prize (2017) in “11th World Immune Regulation Meeting” (Davos,Switzerland) – Mei Li
- Joint USIAS/FRIAS Fellowship - USIAS (Institut d'études Avancées de l'Université de Strasbourg) and FRIAS (l'Institut d’Études Avancées de Fribourg) (2013) – Mei Li
- Prix de Fondation Simone et Cino del Duca de l’Institut de France (2012) – Mei Li
- Prix de Recherche de la Société Française d'Allergologie (2012) – Mei Li
Publications
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2009
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Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma.
- Zhikun Zhang
- Pierre Hener
- Nelly Frossard
- Shigeaki Kato
- Daniel Metzger
- Mei Li
- Pierre Chambon
Proceedings of the National Academy of Sciences of the United States of America ; Volume: 106 ; Page: 1536-41
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Induction of thymic stromal lymphopoietin expression in keratinocytes is necessary for generating an atopic dermatitis upon application of the active vitamin D3 analogue MC903 on mouse skin.
- Mei Li
- Pierre Hener
- Zhikun Zhang
- Krishna P. Ganti
- Daniel Metzger
- Pierre Chambon
Journal of Investigative Dermatology ; Volume: 129 ; Page: 498-502
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2006
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Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.
- Mei Li
- Pierre Hener
- Zhikun Zhang
- Shigeaki Kato
- Daniel Metzger
- Pierre Chambon
Proceedings of the National Academy of Sciences of the United States of America ; Volume: 103 ; Page: 11736-41
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Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes.
- Cécile Calléja
- Nadia Messaddeq
- Benoit Chapellier
- Haiyuan Yang
- Wojciech Krezel
- Mei Li
- Daniel Metzger
- Bénédicte Mascrez
- Kiminori Ohta
- Hiroyuki Kagechika
- Yasuyuki Endo
- Manuel Mark
- Norbert B Ghyselinck
- Pierre Chambon
Genes and Development ; Volume: 20 ; Page: 1525-38
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2005
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Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin.
- Mei Li
- Nadia Messaddeq
- Marius Teletin
- Jean-Louis Pasquali
- Daniel Metzger
- Pierre Chambon
Proceedings of the National Academy of Sciences of the United States of America ; Volume: 102 ; Page: 14795-800
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Targeted somatic mutagenesis in the mouse epidermis.
- Daniel Metzger
- Mei Li
- Pierre Chambon
Methods in Molecular Biology ; Volume: 289 ; Page: 329-40
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2004
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Peroxisome-Proliferator-Activated Receptor (PPAR)-γ Activation Stimulates Keratinocyte Differentiation
- Man Mao-Qiang
- Ashley Fowler
- Matthias Schmuth
- Peggy Lau
- Sandra Chang
- Barbara Brown
- Arthur Moser
- Liliane Michalik
- Beatrice Desvergne
- Walter Wahli
- Mei Li
- Daniel Metzger
- Pierre Chambon
- Peter Elias
- Kenneth Feingold
Journal of Investigative Dermatology ; Volume: 123 ; Page: 305-312
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Tissue-specific and inducible Cre-mediated recombination in the gut epithelium
- Fatima El Marjou
- Klaus-Peter Janssen
- Benny Hung-Junn Chang
- Mei Li
- Valérie Hindie
- Lawrence Chan
- Daniel Louvard
- Pierre Chambon
- Daniel Metzger
- Sylvie Robine
Genesis ; Volume: 39 ; Page: 186-193
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2001
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RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations.
- M Li
- H Chiba
- X Warot
- N Messaddeq
- C Gérard
- P Chambon
- D Metzger
Development (Cambridge, England) ; Volume: 128 ; Page: 675-88
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2000
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Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis
- Mei Li
- Arup Kumar Indra
- Xavier Warot
- Jacques Brocard
- Nadia Messaddeq
- Shigeaki Kato
- Daniel Metzger
- Pierre Chambon
Nature ; Volume: 407 ; Page: 633-636
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