Pathogenesis of inflammatory diseases
Pathogenesis of inflammatory diseases
The conceptual focus of inflammatory diseases has shifted to epithelium (e.g. skin, airway and gut), which besides provides a physical barrier, also plays active roles in initiating and maintaining the inflammatory responses. Our studies from the last years have established the key role of epithelium-derived cytokine thymic stromal lymphopoietin (TSLP) in pathogenesis of atopic diseases including atopic dermatitis and asthma. Moreover, TSLP also emerges as a critical player widely implicated in various inflammatory pathologies, such as inflammatory bowel diseases, autoimmunity and cancer. The goals of our research are to investigate how TSLP expression is dysregulated in pathogenic contexts, to decode the complex cellular and molecular networks driven by TSLP in the inflammatory response, and to explore how such networks are implicated in pathogenesis of a variety of inflammatory diseases notably atopic diseases and cancer. To achieve these goals, we utilize integrated approaches of mouse genetic, pathophysiology-relevant mouse models, cellular and molecular biology, as well as systems biology. Based on the acquired knowledge, we also conduct collaborative studies with clinical researchers, with the ultimate goal to develop new biomarkers and therapeutic/prevention strategies for human inflammatory diseases.
Members
Researchers
PhD students
Engineers
Occasionnal collaborators
Former members
Beatriz Germán Falcón (PhD thesis -2020)
Pierre Marschall (PhD thesis -2019)
Wenjin Yao (PhD thesis -2018)
Carole El Hachem (PhD thesis -2017)
Ruicheng Wei (PhD thesis -2016)
Jiagui Li (PhD thesis -2014)
Juan Manuel Leyva Castillo (PhD thesis -2012)
Zhikun Zhang (PhD thesis – 2008)
Postdoc
Grace Ada Da Silva (2020)
John Lindler (2013-2014)
Simone Reipschlager (2014-2015)
Hua Jiang (2008-2011)
ITA
Pierre Hener (2002-2019)
Jordane Heller (2017-2019)
Cecile Hugel (2019)
Julie Demenez (2019-2020)
Master 2
Marine Guivarch (2021)
Clara Menoret (2020)
Antoine Braud (2020)
Pierre Meyer (2019)
Justine Segaud (2018)
Pierre Marschall (2015)
Current projects
- Cellular and molecular networks driven by TSLP in skin immunity
- TSLP-driven immune networks in the pathogenesis of atopic dermatitis and the atopic march
- Regulation of inflammatory microenvironment associated with cutaneous melanoma
News
Allergies: preventing the progression from atopic dermatitis to asthma
In a study published in the journal Nature Communications, scientists highlight the importance of two proteins in the progression from atopic…
Read more
Awards and recognitions
- Prize for EFIS-EJI Registration Grant in World Immune Regulation Meeting XV (2021) - Justine Segaud
- PhD thesis prize of Foundation of the University of Strasbourg (2021) – Beatriz Germán Falcón
- PhD thesis prize of Strasbourg Biology Society (2021) – Beatriz Germán Falcón
- Prix Charles Grupper - LEO Pharma (2019) – Beatriz Germán Falcón for the publication “Disrupting IL-36 and IL-23/IL-17 loop underlies the efficacy of calcipotriol and corticosteroid therapy for psoriasis. German, B.*, Wei, R.*, Hener, P., Martins, C, Ye, T., Gottwick, C, Yang, J, Seneschal, J., Boniface, K and Li, M. JCI Insight doi: 10.1172/jci.insight.123390.”
- Poster Prize (2018) in “15th International Symposium on Dendritic Cells” (Aachen, Germany) – Pierre Marschall
- IdEx Excellence Prize for "Poster Walk" (2018) in “ 35e Congrès Annuel de la Recherche Dermatologique” (Bordeaux, France) – Wenjin Yao
- Poster Prize (2017) in “11th World Immune Regulation Meeting” (Davos,Switzerland) – Mei Li
- Joint USIAS/FRIAS Fellowship - USIAS (Institut d'études Avancées de l'Université de Strasbourg) and FRIAS (l'Institut d’Études Avancées de Fribourg) (2013) – Mei Li
- Prix de Fondation Simone et Cino del Duca de l’Institut de France (2012) – Mei Li
- Prix de Recherche de la Société Française d'Allergologie (2012) – Mei Li
Publications
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2014
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MicroRNA-146a alleviates chronic skin inflammation in atopic dermatitis through suppression of innate immune responses in keratinocytes
- Ana Rebane
- Toomas Runnel
- Alar Aab
- Julia Maslovskaja
- Beate Rückert
- Maya Zimmermann
- Mario Plaas
- Jaanika Kärner
- Angela Treis
- Maire Pihlap
- Uku Haljasorg
- Helen Hermann
- Nikoletta Nagy
- Lajos Kemeny
- Triin Erm
- Külli Kingo
- Mei Li
- Mark Boldin
- Cezmi Akdis
Journal of Allergy and Clinical Immunology ; Volume: 134 ; Page: 836-847.e11
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Thymic stromal lymphopoietin and atopic diseases
- J.M. Leyva-Castillo
- M. Li
Revue francaise d'allergologie ; Volume: 54 ; Page: 364-376
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Current evidence of epidermal barrier dysfunction and thymic stromal lymphopoietin in the atopic march
- M. Li
European Respiratory Review ; Volume: 23 ; Page: 292-298
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2013
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Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade
- Juan Manuel Leyva-Castillo
- Pierre Hener
- Paula Michea
- Hajime Karasuyama
- Susan Chan
- Vassili Soumelis
- Mei Li
Nature Communications ; Volume: 4
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TSLP Produced by Keratinocytes Promotes Allergen Sensitization through Skin and Thereby Triggers Atopic March in Mice
- Juan Manuel Leyva-Castillo
- Pierre Hener
- Hua Jiang
- Mei Li
Journal of Investigative Dermatology ; Volume: 133 ; Page: 154-163
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2012
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Skin thymic stromal lymphopoietin promotes airway sensitization to inhalant house dust mites leading to allergic asthma in mice
- H. Jiang
- P. Hener
- J. Li
- M. Li
Allergy ; Volume: 67 ; Page: 1078-1082
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Skin TSLP and “atopic march”: What do we learn from mouse models?
- M. Li
Revue francaise d'allergologie ; Volume: 52 ; Page: 324-326
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2011
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Aggravated TSLP-Induced Atopic Dermatitis in Mice Lacking Dicer in Adult Skin Keratinocytes
- Pierre Hener
- Laetitia Friedmann
- Daniel Metzger
- Pierre Chambon
- Mei Li
Journal of Investigative Dermatology ; Volume: 131 ; Page: 2324-2327
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Widespread Negative Response Elements Mediate Direct Repression by Agonist- Liganded Glucocorticoid Receptor
- Milan Surjit
- Krishna priya Ganti
- Atish Mukherji
- Tao Ye
- Guoqiang Hua
- Daniel Metzger
- Mei Li
- Pierre Chambon
Cell ; Volume: 145 ; Page: 224-241
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2009
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Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network
- Laurent Chorro
- Aurélien Sarde
- Mei Li
- Kevin Woollard
- Pierre Chambon
- Bernard Malissen
- Adrien Kissenpfennig
- Jean-Baptiste Barbaroux
- Richard Groves
- Frédéric Geissmann
Journal of Experimental Medicine ; Volume: 206 ; Page: 3089-3100
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