IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Engineers & Technicians

  Valérie ANDRES

  Pascale CHOMARAT

  Gilles DUVAL

  Nicole JUNG

  Dzemailj MEMEDOV

  Mustapha OULAD-ABDELGHANI

Scientific services

Production of monoclonal and polyclonal antibodies

The antibody facility has more than 20 years of experience. It products on request about 40 monoclonal and 200 polyclonal antibodies per year for in-house teams, but also for external academic or industrial clients. Different immunogens (recombinant proteins, polypeptides…) are used for immunization of the mouse, rabbit or rat, allowing to provide a wide range of antibodies.

Mouse monoclonal antibodies available at IGBMC

• Current projects

• Collaborations

  Academic collaborations:
  - P. Fraering, EPFL, Lausanne.
  - E. Weiss, ESBS Illkirch.
  - N Jessel, INSERM U977.
  - B. Chatton, ESBS, Illkirch.
  - E. Borrelli, University of California, Irvine.

  
  Industrial collaborations:
  - Collaboration with Firalis: As part of an agreement with the company Firalis, the MAbF participates to the development of cardiovascular biomarker-based diagnostic.
  The antibody platform collaborates with several other companies for the commercialization of many produced antibodies. 200 antibodies are currently distributed by Millipore, Euromedex, Active-Motif...

• Prizes/Awards

• News

• Publications

  • Selective neutralization of APP-C99 with monoclonal antibodies reduces the production of Alzheimer's A peptides.

    Houacine J, Bolmont T, Aeschbach L, Oulad-Abdelghani M, Fraering PC.

    Neurobiol Aging Nov 2012

  • H3K9 and H3K14 acetylation co-occur at many gene regulatory elements, while H3K14ac marks a subset of inactive inducible promoters in mouse embryonic stem cells.

    Karmodiya K, Krebs AR, Oulad-Abdelghani M, Kimura H, Tora L.

    BMC Genomics Aug. 24, 2012

  • Generation of monoclonal antibody fragments binding the native -secretase complex for use in structural studies.

    Alattia JR, Schweizer C, Cacquevel M, Dimitrov M, Aeschbach L, Oulad-Abdelghani M, Fraering PC.

    Biochemistry Oct. 15, 2012

  • Single-chain Fv fragment antibodies selected from an intrabody library as effective mono- or bivalent reagents for in vitro protein detection

    Desplancq D., Rinaldi A.S., Stoessel A., Sibler A.P., Busso D., Oulad-Abdelghani M., Van Regenmortel M.H., Weiss E.

    J Immunol Methods June 30, 2011

  • Novel molecular diagnostic approaches for X-linked centronuclear (myotubular) myopathy reveal intronic mutations

    Tosch V., Vasli N., Kretz C., Nicot A.S., Gasnier C., Dondaine N., Oriot D., Barth M., Puissant H., Romero N.B., Bonnemann C.G., Heller B., Duval G., Biancalana V., Laporte J.

    Neuromuscul Disord Jun 2010

  • Poly(L-lysine) nanostructured particles for gene delivery and hormone stimulation

    Zhang X., Oulad-Abdelghani M., Zelkin A.N., Wang Y., Haikel Y., Mainard D., Voegel J.C., Caruso F., Benkirane-Jessel N.

    Biomaterials Mar 2010

  • SiRNA-loaded multi-shell nanoparticles incorporated into a multilayered film as a reservoir for gene silencing

    Zhang X., Kovtun A., Mendoza-Palomares C., Oulad-Abdelghani M., Fioretti F., Rinckenbach S., Mainard D., Epple M., Benkirane-Jessel N.

    Biomaterials Aug 2010

  • Helios deficiency has minimal impact on T cell development and function

    Cai Q., Dierich A., Oulad-Abdelghani M., Chan S., Kastner P.

    J Immunol Aug. 15, 2009

  • p38beta2-mediated phosphorylation and sumoylation of ATF7 are mutually exclusive

    Camuzeaux B., Diring J., Hamard P.J., Oulad-Abdelghani M., Donzeau M., Vigneron M., Kedinger C., Chatton B.

    J Mol Biol Dec. 26, 2008

  • Signaling by dopamine regulates D2 receptors trafficking at the membrane

    Tirotta E., Fontaine V., Picetti R., Lombardi M., Samad T.A., Oulad-Abdelghani M., Edwards R., Borrelli E.

    Cell Cycle July 15, 2008

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