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Cells and tissues in 3D with the new FIB-SEM microscope

July 9, 2017

A  new  Focused  Ion  Beam-Scanning  Electron  Microscopy (FIB-SEM)  was  delivered  to  CBI.  This  €  800,000  FRISBI  and  abEx-funded  microscope  aims  to  observe  cellular  or  tissue samples  in  three  dimensions  with  very  high  precision.  The  riginal  technique  is  based  on  the use of two beams: a alium beam (FIB)   which   cuts   extremely   thin   lices  (only  5  nm)  of  the  sample, coupled    to    an    electron beam (SEM) Intracellular organization.

 


By   repeating   these   two   actions many  times,  the  3-D  information is accessed by tomography. This is one of the most accurate methods for    observing    and    quantifying subcellular  structures  at  the  scale  of  an  entire  cell.  Thanks to  the  development  of  algorithms  for  the  analysis  of  the results,   Patrick   Schultz's   team   succeeded   in   quantifying  several  parameters  of  the  cell  nucleus  such  as  the  volume occupied by the nucleus, the chromatin or the nucleolus or to count the exact number of pores. Commissioned in January,this material is destined to be used by the broader scientific community but requires the accompaniment of an expert.

 

For more information, please contact Patrick Schultz.

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