The International Mouse Phenotyping Consortium: a global research infrastructure case study
Oct. 18, 2017
At the G7 Science meeting on 27 and 28 September in Turin, the ministers of higher education and research in these countries identified two projects, including the International Mouse Phenotyping Consortium (IMPC), for which the Clinical Institute of Mice (ICS) is a member, as models of international scientific collaboration.
The group of senior officials (GSO) proactively works to identify opportunities for international collaboration among Research Infrastructures that are proposed by its members: it has identified five Case Studies and has carried out an analysis on their potential as Research Infrastructures for global collaboration. A specific roadmap for implementation has been identified for two of the Case Studies, including the IMPC.
The updated GSO Framework contains a refined definition of global Excellence-driven Access to global research infrastructures that recognises scientific merit as the principal criterion of access. The GSO is also currently addressing the global Open Research Data issue including the key criteria for data management, data quality control and access to data, and sketching a preliminary set of potential guidelines for implementation by global research infrastructures that builds on the results and good practices of, among others, the Research Data Alliance.
Within the IPMC, which brings together 18 international laboratories, The Institut Clinique de la Souris - ICS (Mouse Clinical Insitute - MCI) takes part to a large-scale project: to address the challenge of developing an encyclopedia of mammalian gene function. The IMPC envisages a ten year programme to undertake a broad-based, systematic genome-wide phenotyping project of knockout mice generated from the embryonic stem cell mutant resources.
The ICS generate and study approximately 200 genetically modified mice per year. At the same time, the ICS also pursues the objective of identifying drug candidates thanks to the murine models of human pathologies.