IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Chercheurs

  Christophe ROMIER

• Post-Doctorants

  Nataliia ALEKSANDROVA

  Régis BACK

  Martin MAREK

• Doctorants

  Pernelle KLEIN

  Tajith Baba SHAIK

• Ingénieurs & Techniciens

  Pierre ANTONY

  Sylvie DUCLAUD

• Master

  Elizabeth RAMOS MORALES

Biologie structurale intégrative

Bases Moléculaires de la Régulation de la Chromatine et de la Transcription

Publications

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• Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni.

  Anderson L(1,)(2), Gomes MR(2), daSilva LF(1,)(2), Pereira AD(1,)(2), Mourao MM(3), Romier C(4), Pierce R(5), Verjovski-Almeida S(1,)(2).

  PLoS Negl Trop Dis 13 avril 2017;11:e0005539.

• Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni.

  Marek M(1), Shaik TB(1), Duclaud S(1), Pierce RJ(2), Romier C(3).

  Methods Mol Biol 2016;1436:109-18.

• Complex Reconstitution and Characterization by Combining Co-expression Techniques in Escherichia coli with High-Throughput.

  Vincentelli R(1), Romier C(2).

  Adv Exp Med Biol 2016;896:43-58.

• Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.

  Heimburg T(1), Chakrabarti A(2), Lancelot J(3), Marek M(4), Melesina J(1), Hauser AT(2), Shaik TB(4), Duclaud S(4), Robaa D(1), Erdmann F(1), Schmidt M(1), Romier C(4), Pierce RJ(3), Jung M(2), Sippl W(1).

  J Med Chem 24 mars 2016;59:2423-35.

• Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1.

  Latrick CM(1), Marek M(2), Ouararhni K(1), Papin C(1), Stoll I(1), Ignatyeva M(1), Obri A(1), Ennifar E(3), Dimitrov S(4), Romier C(2), Hamiche A(1).

  Nat Struct Mol Biol Apr 2016;23:309-16.

• Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors.

  Senger J(1), Melesina J(2), Marek M(3), Romier C(3), Oehme I(4), Witt O(4), Sippl W(2), Jung M(1).

  J Med Chem 25 février 2016;59:1545-55.

• Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors.

  Melesina J(1), Robaa D(1), Pierce RJ(2), Romier C(3), Sippl W(4).

  J Mol Graph Model Nov 2015;62:342-61.

• Characterization and production of protein complexes by co-expression in Escherichia coli.

  Haffke M(1), Marek M, Pelosse M, Diebold ML, Schlattner U, Berger I, Romier C.

  Methods Mol Biol 2015;1261:63-89.