IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Chercheurs

  Christophe ROMIER

• Post-Doctorants

  Tajith Baba SHAIK

• Doctorants

  Pernelle KLEIN

  Pauline LANDWERLIN

  Elizabeth RAMOS MORALES

  Marina VITORIA GOMES

  Marina VITORIA GOMES

• Ingénieurs & Techniciens

  Pierre ANTONY

  Sylvie DUCLAUD

Biologie structurale intégrative

Bases Moléculaires de la Régulation de la Chromatine et de la Transcription

Publications

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• Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies.

  Brindisi M(1), Senger J(2), Cavella C(1), Grillo A(1), Chemi G(1), Gemma S(1), Cucinella DM(1), Lamponi S(1), Sarno F(3), Iside C(3), Nebbioso A(3), Novellino E(4), Shaik TB(5), Romier C(5), Herp D(2), Jung M(2), Butini S(6), Campiani G(7), Altucci L(3), Brogi S(1).

  Eur J Med Chem 31 juillet 2018;157:127-138.

• Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis.

  Bayer T(1), Chakrabarti A(2), Lancelot J(3), Shaik TB(4), Hausmann K(1), Melesina J(1), Schmidtkunz K(2), Marek M(4), Erdmann F(1), Schmidt M(1), Robaa D(1), Romier C(4), Pierce RJ(3), Jung M(2), Sippl W(1).

  ChemMedChem Aug 2018;13:1517-1529.

• Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity.

  Lecointre B(1), Narozny R(2), Borrello MT(3), Senger J(4), Chakrabarti A(4), Jung M(4), Marek M(5), Romier C(5), Melesina J(6), Sippl W(6), Bischoff L(1), Ganesan A(7).

  Philos Trans R Soc Lond B Biol Sci 5 juin 2018;373:1-7.

• A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing.

  Simoben CV(1), Robaa D(2), Chakrabarti A(3), Schmidtkunz K(4), Marek M(5), Lancelot J(6), Kannan S(7), Melesina J(8), Shaik TB(9), Pierce RJ(10), Romier C(11), Jung M(12), Sippl W(13).

  Molecules 2 mars 2018;23:E566.

• Microtome-integrated microscope system for high sensitivity tracking of in-resin fluorescence in blocks and ultrathin sections for correlative microscopy.

  Lemercier N(1)(2)(3)(4), Middel V(5), Hentsch D(1)(2)(3)(4), Taubert S(1)(2)(3)(4), Takamiya M(5), Beil T(5), Vonesch JL(1)(2)(3)(4), Baumbach T(6), Schultz P(7)(8)(9)(10), Antony C(1)(2)(3)(4)(5), Strahle U(11).

  Sci Rep 19 octobre 2017;7:13583.

• Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines.

  Stenzel K(1), Hamacher A(1), Hansen FK(1)(2), Gertzen CGW(1), Senger J(3), Marquardt V(1)(4)(5)(6), Marek L(1), Marek M(7), Romier C(7), Remke M(4)(5)(6), Jung M(3), Gohlke H(1), Kassack MU(1), Kurz T(1).

  J Med Chem 13 juillet 2017;60:5334-5348.

• Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups.

  Krieger V(1), Hamacher A(1), Gertzen CGW(1), Senger J(2), Zwinderman MRH(3), Marek M(4), Romier C(4), Dekker FJ(3), Kurz T(1), Jung M(2), Gohlke H(1), Kassack MU(1), Hansen FK(1)(5).

  J Med Chem 13 juillet 2017;60:5493-5506.

• Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni.

  Stenzel K(1), Chakrabarti A(2), Melesina J(3), Hansen FK(1)(4), Lancelot J(5), Herkenhohner S(1), Lungerich B(1), Marek M(6), Romier C(6), Pierce RJ(5), Sippl W(3), Jung M(2), Kurz T(1).

  Arch Pharm (Weinheim) Aug 2017;350:e1700096.