IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Chercheurs

  Christophe ROMIER

• Post-Doctorants

  Nataliia ALEKSANDROVA

  Tajith Baba SHAIK

• Doctorants

  Pernelle KLEIN

  Elizabeth RAMOS MORALES

• Ingénieurs & Techniciens

  Pierre ANTONY

  Sylvie DUCLAUD

Biologie structurale intégrative

Bases Moléculaires de la Régulation de la Chromatine et de la Transcription

Publications

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• Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines.

  Stenzel K(1), Hamacher A(1), Hansen FK(1)(2), Gertzen CGW(1), Senger J(3), Marquardt V(1)(4)(5)(6), Marek L(1), Marek M(7), Romier C(7), Remke M(4)(5)(6), Jung M(3), Gohlke H(1), Kassack MU(1), Kurz T(1).

  J Med Chem 13 juillet 2017;60:5334-5348.

• Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups.

  Krieger V(1), Hamacher A(1), Gertzen CGW(1), Senger J(2), Zwinderman MRH(3), Marek M(4), Romier C(4), Dekker FJ(3), Kurz T(1), Jung M(2), Gohlke H(1), Kassack MU(1), Hansen FK(1)(5).

  J Med Chem 13 juillet 2017;60:5493-5506.

• Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni.

  Stenzel K(1), Chakrabarti A(2), Melesina J(3), Hansen FK(1)(4), Lancelot J(5), Herkenhohner S(1), Lungerich B(1), Marek M(6), Romier C(6), Pierce RJ(5), Sippl W(3), Jung M(2), Kurz T(1).

  Arch Pharm (Weinheim) Aug 2017.

• Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni.

  Anderson L(1,)(2), Gomes MR(2), daSilva LF(1,)(2), Pereira AD(1,)(2), Mourao MM(3), Romier C(4), Pierce R(5), Verjovski-Almeida S(1,)(2).

  PLoS Negl Trop Dis 13 avril 2017;11:e0005539.

• Combattre les maladies negligees en ciblant selectivement leurs enzymes epigenetiques : le cas de la desacetylase 8 (HDAC8) de Schistosoma mansoni.

  Marek M(1), Shaik TB(1), Jung M(2), Sippl W(3), Pierce RJ(4), Romier C(1).

  Biol Aujourdhui 2016;210:311-320.

• Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni.

  Marek M(1), Shaik TB(1), Duclaud S(1), Pierce RJ(2), Romier C(3).

  Methods Mol Biol 2016;1436:109-18.

• Complex Reconstitution and Characterization by Combining Co-expression Techniques in Escherichia coli with High-Throughput.

  Vincentelli R(1), Romier C(2).

  Adv Exp Med Biol 2016;896:43-58.

• Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.

  Heimburg T(1), Chakrabarti A(2), Lancelot J(3), Marek M(4), Melesina J(1), Hauser AT(2), Shaik TB(4), Duclaud S(4), Robaa D(1), Erdmann F(1), Schmidt M(1), Romier C(4), Pierce RJ(3), Jung M(2), Sippl W(1).

  J Med Chem 24 mars 2016;59:2423-35.