The Team
  • Researchers

    Christophe ROMIER

  • Post-Doctoral Fellows

    Nataliia ALEKSANDROVA

    Régis BACK

    Martin MAREK

  • Phd Students

    Tajith Baba SHAIK

  • Engineers & Technicians

    Sylvie DUCLAUD

  • Master

    Elizabeth RAMOS MORALES

Integrated structural Biology

Molecular Basis of Chromatin and Transcription Regulation

The recent deciphering of how chromatin structure and its reorganization by epigenetic mechanisms impact on the regulation of major nuclear processes such as transcription, replication and DNA repair has brought about a profound change in the way we understand and study the regulation of nuclear mechanisms.  Epigenetics research is beginning to unravel the underlying mechanisms of numerous diseases that cannot be explained solely by alterations of the genetic information.

The main research of our group is to decipher in molecular and structural terms the mode of action of epigenetic effectors to understand how they regulate chromatin organization and nuclear mechanisms, and to use this knowledge for therapeutic means.

A major focus of our work concerns histone chaperones, a class of epigenetic effectors involved in the assembly/disassembly of nucleosomes. Our studies on histone chaperone/elongation factor Spt6 has revealed that this chaperone acts as a signal integration platform during transcription elongation by RNA polymerase II. Our work on histone chaperone ANP32E has provided the structural basis for recognition of the histone variant H2A.Z by this chaperone, and enabled us to propose a model for H2A.Z/H2B eviction from chromatin by ANP32E. Beside our work on histone chaperones, we are also implicated in applicative research, seeking for drug leads targeting epigenetic enzymes to cure diseases.

Our current research deals with the study at the molecular and structural levels of macromolecular complexes harboring histone chaperone activities.  Our goal is to decipher the physical and functional links existing between these chaperones and other epigenetic mechanisms such as chromatin modifications, ATP-dependent chromatin remodeling and DNA methylation, to better understand their implication in the regulation of nuclear mechanisms and disease.

Imprimer Envoyer

Université de Strasbourg
INSERM
CNRS

IGBMC - CNRS UMR 7104 - Inserm U 964
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr