IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Researchers

  Christian BRONNER

  Ali HAMICHE

  Christophe PAPIN

  Philippe RAMAIN

  Catherine RAMAIN

• PhD Students

  Naif ALMALKI

  Arslan IFTIKHAR

  Hatem SALEM

  Alexia VIDAL

  Dimitra VLACHOKOSTA

• Engineers & Technicians

  Isabelle STOLL

Functional genomics and cancer

Chromatin and epigenetic regulation

Publications

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• Coordinated Dialogue between UHRF1 and DNMT1 to Ensure Faithful Inheritance of Methylated DNA Patterns.

  Bronner C(1), Alhosin M(2), Hamiche A(3), Mousli M(4).

  Genes (Basel) Jan. 18, 2019.

• Centromeric and ectopic assembly of CENP-A chromatin in health and cancer: old marks and new tracks.

  Sharma AB(1), Dimitrov S(2)(3), Hamiche A(4), Van Dyck E(1).

  Nucleic Acids Res Dec. 27, 2018.

• Identification of Deregulated Signaling Pathways in Jurkat Cells in Response to a Novel Acylspermidine Analogue-N4-Erucoyl Spermidine.

  Razvi SS(1), Choudhry H(1)(2)(3)(4), Hasan MN(1), Hassan MA(1)(5), Moselhy SS(1)(4)(6)(7), Abualnaja KO(1)(4)(6), Zamzami MA(1)(2)(3), Kumosani TA(1)(4)(8), Al-Malki AL(1)(4)(6), Halwani MA(9), Ibrahim A(10), Hamiche A(10), Bronner C(10), Asami T(1)(11), Alhosin M(1)(2)(3).

  Epigenet Insights Nov. 27, 2018;11:2516865718814543.

• Structure of an H1-Bound 6-Nucleosome Array Reveals an Untwisted Two-Start Chromatin Fiber Conformation.

  Garcia-Saez I(1), Menoni H(2), Boopathi R(2), Shukla MS(2), Soueidan L(2), Noirclerc-Savoye M(1), Le Roy A(1), Skoufias DA(1), Bednar J(3), Hamiche A(4), Angelov D(5), Petosa C(6), Dimitrov S(7).

  Mol Cell Oct. 22, 2018.

• Thymoquinone challenges UHRF1 to commit auto-ubiquitination: a key event for apoptosis induction in cancer cells.

  Ibrahim A(1)(2), Alhosin M(3)(4), Papin C(1), Ouararhni K(1), Omran Z(5), Zamzami MA(3)(4), Al-Malki AL(3), Choudhry H(3)(4), Mely Y(6), Hamiche A(1), Mousli M(6), Bronner C(1).

  Oncotarget June 19, 2018;9:28599-28611.

• 3DClusterViSu: 3D clustering analysis of super-resolution microscopy data by 3D Voronoi tessellations.

  Andronov L(1)(2)(3)(4), Michalon J(1)(2)(3)(4), Ouararhni K(1)(2)(3)(4), Orlov I(1)(2)(3)(4), Hamiche A(1)(2)(3)(4), Vonesch JL(1)(2)(3)(4), Klaholz BP(1)(2)(3)(4).

  Bioinformatics April 4, 2018.

• Targeting microRNA/UHRF1 pathways as a novel strategy for cancer therapy.

  Choudhry H(1)(2)(3)(4), Zamzami MA(1)(2)(3), Omran Z(5), Wu W(6), Mousli M(7), Bronner C(8), Alhosin M(1)(2)(3).

  Oncol Lett Jan 2018;15:3-10.

• Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell.

  Ashraf W(1), Bronner C(2), Zaayter L(1), Ahmad T(1), Richert L(1), Alhosin M(3)(4), Ibrahim A(2)(5), Hamiche A(2), Mely Y(1), Mousli M(6).

  J Exp Clin Cancer Res Dec. 21, 2017;36:188.