IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Researchers

  Christian BRONNER

  Ali HAMICHE

  Christophe PAPIN

  Philippe RAMAIN

  Catherine RAMAIN

• Post-Doctoral Fellows

  Abdulkhaleg IBRAHIM

• PhD Students

  Naif ALMALKI

  Arslan IFTIKHAR

  Hatem SALEM

  Alexia VIDAL

  Dimitra VLACHOKOSTA

• Engineers & Technicians

  Isabelle STOLL

Functional genomics and cancer

Chromatin and epigenetic regulation

Publications

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• A molecular tool targeting the base flipping activity of human UHRF1.

  Zaayter L(1), Mori M(2), Ahmad T(1), Ashraf W(1), Boudier C(1), Kilin V(1), Gavvala K(1), Richert L(1), Eiler S(3), Ruff M(3), Botta M(2), Bronner C(3), Mousli M(1), Mely Y(4).

  Chemistry July 19, 2019.

• Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors.

  Vogerl K(1), Ong N(1), Senger J(2), Herp D(2), Schmidtkunz K(2), Marek M(3), Muller M(1), Bartel K(1), Shaik TB(3), Porter NJ(4), Robaa D(5), Christianson DW(4), Romier C(3), Sippl W(5), Jung M(2), Bracher F(1).

  J Med Chem Feb. 14, 2019;62:1138-1166.

• Coordinated Dialogue between UHRF1 and DNMT1 to Ensure Faithful Inheritance of Methylated DNA Patterns.

  Bronner C(1), Alhosin M(2), Hamiche A(3), Mousli M(4).

  Genes (Basel) Jan. 18, 2019;10:E65.

• Centromeric and ectopic assembly of CENP-A chromatin in health and cancer: old marks and new tracks.

  Sharma AB(1), Dimitrov S(2)(3), Hamiche A(4), Van Dyck E(1).

  Nucleic Acids Res Feb. 20, 2019;47:1051-1069.

• Identification of Deregulated Signaling Pathways in Jurkat Cells in Response to a Novel Acylspermidine Analogue-N4-Erucoyl Spermidine.

  Razvi SS(1), Choudhry H(1)(2)(3)(4), Hasan MN(1), Hassan MA(1)(5), Moselhy SS(1)(4)(6)(7), Abualnaja KO(1)(4)(6), Zamzami MA(1)(2)(3), Kumosani TA(1)(4)(8), Al-Malki AL(1)(4)(6), Halwani MA(9), Ibrahim A(10), Hamiche A(10), Bronner C(10), Asami T(1)(11), Alhosin M(1)(2)(3).

  Epigenet Insights Nov. 27, 2018;11:2516865718814543.

• Structure of an H1-Bound 6-Nucleosome Array Reveals an Untwisted Two-Start Chromatin Fiber Conformation.

  Garcia-Saez I(1), Menoni H(2), Boopathi R(2), Shukla MS(2), Soueidan L(2), Noirclerc-Savoye M(1), Le Roy A(1), Skoufias DA(1), Bednar J(3), Hamiche A(4), Angelov D(5), Petosa C(6), Dimitrov S(7).

  Mol Cell Dec. 6, 2018;72:902-915.e7.

• Thymoquinone challenges UHRF1 to commit auto-ubiquitination: a key event for apoptosis induction in cancer cells.

  Ibrahim A(1)(2), Alhosin M(3)(4), Papin C(1), Ouararhni K(1), Omran Z(5), Zamzami MA(3)(4), Al-Malki AL(3), Choudhry H(3)(4), Mely Y(6), Hamiche A(1), Mousli M(6), Bronner C(1).

  Oncotarget June 19, 2018;9:28599-28611.

• 3DClusterViSu: 3D clustering analysis of super-resolution microscopy data by 3D Voronoi tessellations.

  Andronov L(1)(2)(3)(4), Michalon J(1)(2)(3)(4), Ouararhni K(1)(2)(3)(4), Orlov I(1)(2)(3)(4), Hamiche A(1)(2)(3)(4), Vonesch JL(1)(2)(3)(4), Klaholz BP(1)(2)(3)(4).

  Bioinformatics Sept. 1, 2018;34:3004-3012.