IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Researchers

  Didier DEVYS

  Laszlo TORA

  Stéphane VINCENT

• Post-Doctoral Fellows

  Farrah EL SAAFIN

• PhD Students

  Véronique FISCHER

  Vincent HISLER

  Pooja MUKHERJEE

  Kenny SCHUMACHER

  Fang WANG

• Engineers & Technicians

  Elisabeth SCHEER

  Matthieu STIERLE

Development and stem cells

Dynamics of chromatin structure and transcription regulation

Publications

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• Co-translational assembly of mammalian nuclear multisubunit complexes.

  Kamenova I(1)(2)(3)(4), Mukherjee P(1)(2)(3)(4), Conic S(1)(2)(3)(4), Mueller F(5), El-Saafin F(1)(2)(3)(4), Bardot P(1)(2)(3)(4), Garnier JM(1)(2)(3)(4), Dembele D(1)(2)(3)(4), Capponi S(6), Timmers HTM(6), Vincent SD(1)(2)(3)(4), Tora L(7)(8)(9)(10).

  Nat Commun April 15, 2019;10:1740.

• Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression.

  Sandoz J(1)(2)(3)(4), Nagy Z(1)(2)(3)(4), Catez P(1)(2)(3)(4), Caliskan G(1)(2)(3)(4), Geny S(5), Renaud JB(5), Concordet JP(5), Poterszman A(1)(2)(3)(4), Tora L(1)(2)(3)(4), Egly JM(1)(2)(3)(4), Le May N(1)(2)(3)(4), Coin F(6)(7)(8)(9).

  Nat Commun March 20, 2019;10:1288.

• Global role for coactivator complexes in RNA polymerase II transcription.

  Fischer V(1)(2)(3)(4), Schumacher K(1)(2)(3)(4), Tora L(1)(2)(3)(4), Devys D(1)(2)(3)(4).

  Transcription Feb 2019;10:29-36.

• Uniform Widespread Nuclear Phosphorylation of Histone H2AX Is an Indicator of Lethal DNA Replication Stress.

  Moeglin E(1), Desplancq D(2), Conic S(3)(4)(5)(6), Oulad-Abdelghani M(7)(8)(9)(10), Stoessel A(11), Chiper M(12), Vigneron M(13), Didier P(14), Tora L(15)(16)(17)(18), Weiss E(19).

  Cancers (Basel) March 13, 2019.

• A cell cycle-coordinated Polymerase II transcription compartment encompasses gene expression before global genome activation.

  Hadzhiev Y(1), Qureshi HK(1), Wheatley L(1), Cooper L(1), Jasiulewicz A(1), Van Nguyen H(2), Wragg JW(1), Poovathumkadavil D(1), Conic S(3)(4), Bajan S(5), Sik A(6)(7), Hutvagner G(5), Tora L(3)(4), Gambus A(1), Fossey JS(2), Muller F(8).

  Nat Commun Feb. 11, 2019;10:691.

• Chaperonin CCT checkpoint function in basal transcription factor TFIID assembly.

  Antonova SV(1), Haffke M(2)(3), Corradini E(4), Mikuciunas M(1), Low TY(4)(5), Signor L(6), van Es RM(7), Gupta K(8), Scheer E(9)(10)(11)(12), Vos HR(7), Tora L(9)(10)(11)(12), Heck AJR(4), Timmers HTM(13)(14)(15), Berger I(16).

  Nat Struct Mol Biol Dec. 3, 2018.

• Electroporation of Labeled Antibodies to Visualize Endogenous Proteins and Posttranslational Modifications in Living Metazoan Cell Types.

  Conic S(1)(2)(3)(4), Desplancq D(4)(5), Tora L(1)(2)(3)(4), Weiss E(4)(5).

  Bio Protoc Nov. 5, 2018.

• Saccharomyces cerevisiae Metabolic Labeling with 4-thiouracil and the Quantification of Newly Synthesized mRNA As a Proxy for RNA Polymerase II Activity.

  Baptista T(1), Devys D(2).

  J Vis Exp Oct. 22, 2018.