IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Chercheurs

  Didier DEVYS

  Laszlo TORA

  Stéphane VINCENT

• Post-Doctorants

  Farrah EL SAAFIN

• Doctorants

  Véronique FISCHER

  Vincent HISLER

  Pooja MUKHERJEE

  Kenny SCHUMACHER

  Fang WANG

  Changwei YU

• Ingénieurs & Techniciens

  Elisabeth SCHEER

  Matthieu STIERLE

• Collaborateur Occasionnel

  Gizem CALISKAN

Biologie du développement et cellules souches

Modifications de la chromatine et régulation de la transcription des gènes lors de la différentiation cellulaire

Publications

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• Transcript Buffering: A Balancing Act between mRNA Synthesis and mRNA Degradation.

  Timmers HTM(1), Tora L(2).

  Mol Cell 4 octobre 2018;72:10-17.

• Mediator is essential for small nuclear and nucleolar RNA transcription in yeast.

  Tourigny JP(1), Saleh MM(1), Schumacher K(2)(3)(4)(5), Devys D(2)(3)(4)(5), Zentner GE(6)(7).

  Mol Cell Biol 1 octobre 2018.

• Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair.

  Evangelista FM(1)(2)(3)(4), Maglott-Roth A(1)(2)(3)(4), Stierle M(1)(2)(3)(4), Brino L(1)(2)(3)(4), Soutoglou E(5)(2)(3)(4), Tora L(6)(2)(3)(4).

  J Cell Biol Oct 2018;217:3382-3397.

• Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA polymerase II transcription.

  El-Saafin F(1)(2)(3)(4), Curry C(5)(6), Ye T(1)(2)(3)(4), Garnier JM(1)(2)(3)(4), Kolb-Cheynel I(1)(2)(3)(4), Stierle M(1)(2)(3)(4), Downer NL(7), Dixon MP(7), Negroni L(1)(2)(3)(4), Berger I(8), Thomas T(7)(9), Voss AK(7)(9), Dobyns W(10)(11), Devys D(1)(2)(3)(4), Tora L(1)(2)(3)(4).

  Hum Mol Genet 15 juin 2018;27:2171-2186.

• Imaging of native transcription factors and histone phosphorylation at high resolution in live cells.

  Conic S(1)(2)(3)(4), Desplancq D(5), Ferrand A(6), Fischer V(1)(2)(3)(4), Heyer V(1)(2)(3)(4), Reina San Martin B(1)(2)(3)(4), Pontabry J(1)(2)(3)(4)(7), Oulad-Abdelghani M(1)(2)(3)(4), Babu N K(8), Wright GD(9), Molina N(1)(2)(3)(4), Weiss E(10), Tora L(11)(2)(3)(4)(8).

  J Cell Biol 2 avril 2018;217:1537-1552.

• Architecture of TAF11/TAF13/TBP complex suggests novel regulation properties of general transcription factor TFIID.

  Gupta K(1), Watson AA(2), Baptista T(3), Scheer E(3), Chambers AL(1), Koehler C(4), Zou J(5), Obong-Ebong I(6), Kandiah E(7), Temblador A(7), Round A(7), Forest E(8), Man P(9), Bieniossek C(7), Laue ED(2), Lemke EA(4), Rappsilber J(5), Robinson CV(6), Devys D(3), Tora L(3), Berger I(1).

  Elife 7 novembre 2017;6:e30395.

• YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer.

  Mi W(1)(2), Guan H(3)(4), Lyu J(5), Zhao D(3)(4), Xi Y(5), Jiang S(1)(2), Andrews FH(6), Wang X(1)(2), Gagea M(7), Wen H(1)(2), Tora L(8)(9)(10)(11), Dent SYR(1)(2)(12), Kutateladze TG(6), Li W(13), Li H(14)(15), Shi X(16)(17)(18).

  Nat Commun 20 octobre 2017;8:1088.

• The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo.

  Bardot P(1)(2)(3)(4), Vincent SD(5)(2)(3)(4), Fournier M(1)(2)(3)(4), Hubaud A(1)(2)(3)(4), Joint M(1)(2)(3)(4), Tora L(1)(2)(3)(4), Pourquie O(1)(2)(3)(4).

  Development 15 octobre 2017;144:3808-3818.