IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Chercheurs

  Didier DEVYS

  Laszlo TORA

  Stéphane VINCENT

• Post-Doctorants

  Farrah EL SAAFIN

  Ivanka KAMENOVA

• Doctorants

  Paul BARDOT

  Sascha CONIC

  Federica EVANGELISTA

  Tiago FIDALGO BAPTISTA

  Véronique FISCHER

  Pooja MUKHERJEE

  Changwei YU

• Ingénieurs & Techniciens

  Elisabeth SCHEER

  Matthieu STIERLE

Biologie du développement et cellules souches

Modifications de la chromatine et régulation de la transcription des gènes lors de la différentiation cellulaire

Publications

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• Coactivators and general transcription factors have two distinct dynamic populations dependent on transcription.

  Vosnakis N(1)(2)(3)(4), Koch M(1)(2)(3)(4), Scheer E(1)(2)(3)(4), Kessler P(1)(2)(3)(4), Mely Y(4)(5), Didier P(4)(5), Tora L(6)(2)(3)(4).

  EMBO J 19 juillet 2017.

• KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number.

  Fournier M(1), Tora L(2).

  Mol Cell Oncol 16 décembre 2016;4:e1270391.

• KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.

  Fournier M(1,)(2,)(3,)(4,)(5), Orpinell M(6), Grauffel C(1,)(2,)(3,)(4), Scheer E(1,)(2,)(3,)(4), Garnier JM(1,)(2,)(3,)(4), Ye T(1,)(2,)(3,)(4), Chavant V(1,)(2,)(3,)(4), Joint M(1,)(2,)(3,)(4), Esashi F(5), Dejaegere A(1,)(2,)(3,)(4), Gonczy P(6), Tora L(1,)(2,)(3,)(4).

  Nat Commun 31 octobre 2016;7:13227.

• Targeting the replisome with transduced monoclonal antibodies triggers lethal DNA replication stress in cancer cells.

  Desplancq D(1), Freund G(1), Conic S(2), Sibler AP(1), Didier P(3), Stoessel A(1), Oulad-Abdelghani M(2), Vigneron M(1), Wagner J(1), Mély Y(3), Chatton B(1), Tora L(2), Weiss E(4).

  Exp Cell Res 8 mars 2016;342:145-158.

• TBP/TFIID-dependent activation of MyoD target genes in skeletal muscle cells.

  Malecova B(1), Dall'Agnese A(1), Madaro L(2), Gatto S(1), Coutinho Toto P(1), Albini S(1), Ryan T(1), Tora L(3), Puri PL(1,)(2).

  Elife 25 février 2016;5:E12534.

• Systems biology approaches bring new insights in the understanding of global gene regulatory mechanisms and their deregulation in cancer

  Krebs Arnaud and Tora László

  Systems Biology of Cancer avr 2015 2015;PT 2:56-69.

• dTAF10- and dTAF10b-Containing Complexes Are Required for Ecdysone-Driven Larval-Pupal Morphogenesis in Drosophila melanogaster.

  Pahi Z(1), Kiss Z(1), Komonyi O(1), Borsos BN(1), Tora L(2), Boros IM(1,)(3), Pankotai T(1,)(3).

  PLoS One 10 novembre 2015;10:e0142226.

• Subunits of ADA-two-A-containing (ATAC) or Spt-Ada-Gcn5-acetyltrasferase (SAGA) Coactivator Complexes Enhance the Acetyltransferase Activity of GCN5.

  Riss A(1), Scheer E(1), Joint M(2), Trowitzsch S(3), Berger I(3), Tora L(4).

  J Biol Chem 27 novembre 2015;290:28997-9009.