The Team
  • Researchers

    Bill KEYES

Development and stem cells

Common Mechanisms of Development, Cancer and Aging

Cellular senescence is a form of cell cycle arrest that acts a potent tumor suppressive mechanism. In addition, it can also contribute to organismal aging and stem cell decline. However, there are aspects to senescence, such as the secretion by senescent cells of growth factors, cytokines and extracellular remodeling factors (the senescence-associated secretory phenotype, or “SASP”) that suggested more complex functions for the senescent state. While investigating possible non-classical functions for senescence, we discovered cellular senescence as a normal programmed process during embryonic development. Interestingly, senescence in the embryo is mediated by the expression of p21, exhibits features of the SASP, and instructs local tissue patterning and remodeling. Subsequently, the senescent cells are removed by apoptosis and macrophage-mediated clearance. This discovery opens up exciting new avenues to unravel the biological importance of the senescence program, its role in embryonic development and patterning, and the correlations with its function in cancer and aging.


Our lab is interested in understanding the biological role and molecular mechanisms regulating cellular senescence in different contexts, including during normal embryonic development, in tissue regeneration and aging, and in tumor development.


The team is being installed

Imprimer Envoyer

Université de Strasbourg

IGBMC - CNRS UMR 7104 - Inserm U 964
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 /