The Team
  • Researchers

    Bertrand BENAZERAF

    Karine GUEVORKIAN

    Olivier POURQUIE

    Stéphane VINCENT

  • Post-Doctoral Fellows

    Gonçalo CADETE VILHAIS NETO

  • Phd Students

    Arthur MICHAUT

  • Engineers & Technicians

    Tania KNAUER-MEYER

    Jean-Luc PLASSAT

    Olivier TASSY

  • Administrative Assistant

    Myriam REBETEZ

Development and stem cells

Development of muscle and vertebrae

We are interested in the mechanisms controlling the formation of the body of vertebrates during embryogenesis. In particular, we have been focusing on the process of axis elongation and on segmentation whereby a periodic series of anatomical structures such as vertebrae are formed during organogenesis. Our work relies on developmental biology studies in chicken, mouse and zebrafish embryos combining genetic approaches with genomic strategies such as transcriptomics or high throughput sequencing and bioinformatics as well as sophisticated in vivo imaging. Our goal is to understand the basic principles underlying these morphogenetic processes. We are actively collaborating with physicists and mathematicians to attempt to model these complex molecular and cellular processes in the embryo.
Equally we are interested in the clinical relevance of these findings and are exploring the molecular basis of spine patterning defects such as scoliosis in humans. Lastly, we are moving into the field of regenerative medicine, translating our understanding of differentiation of the muscle and vertebral lineages into in vitro strategies to differentiate mouse and human embryonic or reprogrammed stem cells for cellular therapies of degenerative diseases such as Duchenne muscular dystrophy.

  • Current projects

  • Collaborations

    - Dr. Andy Oates, Allemagne « Evolutionary plasticity of the segementation clock networks »
    - Dr. Paul François, USA «  A random cell motility downstream of FGF controls elongation of an amniote embryo »
    - Dr. Albert Goldbeter, Belgique « Modeling the segementation clock as a network coupled oscillations in the Notch Wnt and FGF signaling pathways »
    - Dr. Ruth Baker, UK «  A random cell motility downstream of FGF controls elongation of an amniote embryo »

  • Prizes/Awards

    • Olivier POURQUIE - Richard Lounsbery Prize - Institut de France de l'Académie des Sciences - 2012
    • Olivier POURQUIE - Program grant - Human Frontier Science Program (HFSP) - 2012
    • Olivier POURQUIE - Allianz Prize - Institut de France de l'Académie des Sciences - 2011
    • Olivier POURQUIE - ERC Advanced grant - European Research Council (ERC) - 2009
    • Olivier POURQUIE - Victor Noury prize - Institut de France de l'Académie des Sciences / National Academy of sciences - 2005
    • Olivier POURQUIE - Edouard Van Beneden prize - Académie royale de Belgique - 2005
    • Olivier POURQUIE - Harland Winfield Mossman Developmental Biologist Award - American Association of Anatomists - 2004
    • Olivier POURQUIE - Member of the European Molecular Biology Organization - European Molecular Biology Organization (EMBO) - 2002
    • Olivier POURQUIE - Scientific prize - Fondation Gulbenkian - 1998
    • Olivier POURQUIE - Bronze medal - CNRS - 1996
  • News

  • Publications

    • Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitro.

      Chal J(1,)(2,)(3,)(4), Al Tanoury Z(1), Hestin M(2,)(3,)(4), Gobert B(1), Aivio S(2,)(3,)(4), Hick A(5), Cherrier T(1), Nesmith AP(6), Parker KK(6), Pourquié O(1,)(2,)(3,)(4).

      Nat Protoc Oct 2016 ; 11:1833-50 .

    • Extracellular matrix motion and early morphogenesis.

      Loganathan R(1), Rongish BJ(2), Smith CM(3), Filla MB(2), Czirok A(4), Bénazéraf B(5), Little CD(6).

      Development June 15, 2016 ; 143:2056-65 .

    • High-throughput discovery of novel developmental phenotypes.

      Dickinson ME(1), Flenniken AM(2,)(3), Ji X(4), Teboul L(5), Wong MD(2,)(6), White JK(7), Meehan TF(8), Weninger WJ(9), Westerberg H(5), Adissu H(2,)(10), Baker CN(11), Bower L(12), Brown JM(5), Caddle LB(11), Chiani F(13), Clary D(12), Cleak J(5), Daly MJ(14,)(15), Denegre JM(11), Doe B(7), Dolan ME(11), Edie SM(11), Fuchs H(16), Gailus-Durner V(16), Galli A(7), Gambadoro A(13), Gallegos J(17), Guo S(18), Horner NR(5), Hsu CW(1), Johnson SJ(5), Kalaga S(1), Keith LC(1), Lanoue L(12), Lawson TN(5), Lek M(14,)(15), Mark M(19), Marschall S(16), Mason J(8), McElwee ML(1), Newbigging S(2,)(10), Nutter LM(2,)(10), Peterson KA(11), Ramirez-Solis R(7), Rowland DJ(12), Ryder E(7), Samocha KE(14,)(15), Seavitt JR(17), Selloum M(19), Szoke-Kovacs Z(5), Tamura M(20), Trainor AG(12), Tudose I(8), Wakana S(20), Warren J(8), Wendling O(19), West DB(21), Wong L(1), Yoshiki A(20); International Mouse Phenotyping Consortium; Jackson Laboratory; Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource Center, MacArthur DG(14,)(15), Tocchini-Valentini GP(13), Gao X(18), Flicek P(8), Bradley A(7), Skarnes WC(7), Justice MJ(10,)(17), Parkinson HE(8), Moore M(22), Wells S(5), Braun RE(11), Svenson KL(11), de Angelis MH(16,)(23,)(24), Herault Y(19), Mohun T(25), Mallon AM(5), Henkelman RM(2,)(6), Brown SD(5), Adams DJ(7), Lloyd KC(12), McKerlie C(2,)(10), Beaudet AL(17), Bu?an M(26), Murray SA(11).

      Nature Sept. 14, 2016 .

    • High-throughput discovery of novel developmental phenotypes.

      Dickinson ME(1), Flenniken AM(2,)(3), Ji X(4), Teboul L(5), Wong MD(2,)(6), White JK(7), Meehan TF(8), Weninger WJ(9), Westerberg H(5), Adissu H(2,)(10), Baker CN(11), Bower L(12), Brown JM(5), Caddle LB(11), Chiani F(13), Clary D(12), Cleak J(5), Daly MJ(14,)(15), Denegre JM(11), Doe B(7), Dolan ME(11), Edie SM(11), Fuchs H(16), Gailus-Durner V(16), Galli A(7), Gambadoro A(13), Gallegos J(17), Guo S(18), Horner NR(5), Hsu CW(1), Johnson SJ(5), Kalaga S(1), Keith LC(1), Lanoue L(12), Lawson TN(5), Lek M(14,)(15), Mark M(19), Marschall S(16), Mason J(8), McElwee ML(1), Newbigging S(2,)(10), Nutter LM(2,)(10), Peterson KA(11), Ramirez-Solis R(7), Rowland DJ(12), Ryder E(7), Samocha KE(14,)(15), Seavitt JR(17), Selloum M(19), Szoke-Kovacs Z(5), Tamura M(20), Trainor AG(12), Tudose I(8), Wakana S(20), Warren J(8), Wendling O(19), West DB(21), Wong L(1), Yoshiki A(20); International Mouse Phenotyping Consortium; Jackson Laboratory; Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource Center, MacArthur DG(14,)(15), Tocchini-Valentini GP(13), Gao X(18), Flicek P(8), Bradley A(7), Skarnes WC(7), Justice MJ(10,)(17), Parkinson HE(8), Moore M(22), Wells S(5), Braun RE(11), Svenson KL(11), de Angelis MH(16,)(23,)(24), Herault Y(19), Mohun T(25), Mallon AM(5), Henkelman RM(2,)(6), Brown SD(5), Adams DJ(7), Lloyd KC(12), McKerlie C(2,)(10), Beaudet AL(17), Bu?an M(26), Murray SA(11).

      Nature Sept. 14, 2016 .

    • Convergent Signaling Pathways Controlled by LRP1 (Receptor-related Protein 1) Cytoplasmic and Extracellular Domains Limit Cellular Cholesterol Accumulation.

      El Asmar Z(1), Terrand J(1), Jenty M(1), Host L(1), Mlih M(1), Zerr A(1), Justiniano H(1), Matz RL(1), Boudier C(1), Scholler E(1), Garnier JM(2), Bertaccini D(3), Thiersé D(3), Schaeffer C(3), Van Dorsselaer A(3), Herz J(4), Bruban V(5), Boucher P(6).

      J Biol Chem March 4, 2016 ; 291:5116-27 .

    • An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression.

      Darcis G(1), Kula A(2), Bouchat S(2), Fujinaga K(3), Corazza F(4), Ait-Ammar A(5), Delacourt N(2), Melard A(6), Kabeya K(7), Vanhulle C(2), Van Driessche B(2), Gatot JS(8), Cherrier T(9), Pianowski LF(10), Gama L(11), Schwartz C(5), Vila J(2), Burny A(2), Clumeck N(7), Moutschen M(12), De Wit S(7), Peterlin BM(3), Rouzioux C(6), Rohr O(13), Van Lint C(2).

      PLoS Pathog July 30, 2015 ; 11:e1005063 .

    • Developing a new look.

      Pourquié O(1), Brown K(2), Moulton C(2).

      Development Nov. 15, 2015 ; 142:3803-4 .

    • Mechanics of Biomimetic Liposomes Encapsulating an Actin Shell.

      Guevorkian K(1), Manzi J(2), Pontani LL(3), Brochard-Wyart F(2), Sykes C(4).

      Biophys J Dec. 15, 2015 ; 109:2471-9 .

    • Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy.

      Chal J(1,)(2,)(3,)(4,)(5), Oginuma M(1), Al Tanoury Z(1), Gobert B(1), Sumara O(1), Hick A(6), Bousson F(6), Zidouni Y(1), Mursch C(1), Moncuquet P(1), Tassy O(1), Vincent S(1), Miyanari A(1), Bera A(1), Garnier JM(1), Guevara G(3,)(4,)(5), Hestin M(3,)(4,)(5), Kennedy L(1), Hayashi S(7,)(8), Drayton B(7,)(8), Cherrier T(1), Gayraud-Morel B(9), Gussoni E(10), Relaix F(7,)(8), Tajbakhsh S(9), Pourquié O(1,)(2,)(3,)(4,)(5,)(11).

      Nat Biotechnol Sep 2015 ; 33:962-9 .

    • A transgenic quail model that enables dynamic imaging of amniote embryogenesis.

      Huss D(1), Benazeraf B(2), Wallingford A(3), Filla M(4), Yang J(5), Fraser SE(6), Lansford R(7).

      Development Aug. 15, 2015 ; 142:2850-9 .

    See all publications=>

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