4 research departments
750 employees
45 nationalities
55 research teams
16 ERC laureates
260 publications per year
24000 m² lab area

Support us through

Fondation universite de Strasbourg

photo

Head

Manuel MENDOZA
manuel.mendoza@igbmc.fr

Key figures

52 research teams
138 researchers
48 post-doctoral fellows
93 PhD students
133 engineers & technicians
117 administrators & general services 110 ICS employees

Quick Links

Job opportunities

Control Of Cell Identity By Modulation Of Nuclear Pore Complexes

Reference : PhD Manuel Mendoza

Offer publication : Jan. 24, 2018

Asymmetric cell division is a key strategy to generate cellular diversity during the development of organisms. Nuclear pore complexes (NPCs) mediate communication between the nucleus and the cytoplasm, and also regulate gene nuclear position and expression through interactions with chromatin. Interestingly, the acquisition of cellular identity is coupled to changes in NPC composition, but whether and how these changes determine cell fate remains unclear.

 

We recently discovered that modulation of NPCs by lysine deacetylation leads to establishment of cell identity in budding yeast daughter cells, through regulation of both nucleo-cytoplasmic transport and gene positioning. Thus, NPC deacetylation is a differentiation switch in asymmetrically dividing budding yeast, raising the possibility that similar mechanisms might establish cell identity in animal cells. The student in charge of this project will help characterize how NPC deacetylation leads to cell fate specification, and shapes nuclear transport and three-dimensional nuclear organization.Characterizationofthis new cell fate establishment mechanism will reveal novel principles of animal stem cell self-renewal and tissue homeostasis, and of human pathologies associated with defects in these processes, including microcephaly and cancer.

Your application

Application Deadline : Nov. 1, 2018

Imprimer Envoyer

Université de Strasbourg
INSERM
CNRS

IGBMC - CNRS UMR 7104 - Inserm U 1258
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr