4 research departments
750 employees
45 nationalities
55 research teams
16 ERC laureates
260 publications per year
24000 m² lab area

Support us through

Fondation universite de Strasbourg

Key figures 2018

8 congresses, workshops and meetings
3 special seminars
0 internal seminars
31 thesis


Quick Links


Roles for Growth factors in Tumor Progression: Opportunities for Cancer Therapy

Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel

Friday, December 7th 2018 - 11 a.m. - Auditorium, IGBMC
Hosted by Fabien ALPY & Catherine-Laure TOMASETTO

While the majority of tumors are initiated by genetic aberrations, all malignant lesions follow a subsequent step-wise progression phase, which involves growth factors and their cognate receptors. Unlike many oncogenic mutations, growth factors and their receptor tyrosine kinases are amenable to pharmacological interception. My lecture will focus on the group of EGF-like growth factors and their ERBB/HER family receptors. I will highlight the principles of signal transduction networks and focus on the complex transcriptional programs that underlay EGF-to-ERBB signaling. The second part of my lecture will exemplify the opportunities offered by pharmacological targeting of growth factor signaling, including clinically approved drugs, experimental strategies and ways to overcome resistance to molecular targeted therapies.

Event poster

Imprimer Envoyer

Université de Strasbourg

IGBMC - CNRS UMR 7104 - Inserm U 1258
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr