4 départements de recherche
750 employés
45 nationalités
55 équipes de recherche
16 lauréats ERC
260 publications par an
24000 m² de laboratoires

Soutenez-nous via

Fondation universite de Strasbourg

Séminaire

Implications of transcriptional mechanism for cell decision-making

Dr Jonathan CHUBB
MRC LMCB, Londres, Royaume-Uni

lundi 11 février 2019 - 09h30 - Auditorium, IGBMC
Invité(e) par Nacho MOLINA

Gene transcription is discontinuous, occurring in “bursts or “pulses”.  Although transcriptions bursts are conserved in all forms of life, from bacteria through to cells in mammalian tissues, the causes and consequences of bursting are unclear.  My talk will explore our recent progress in answering these questions.  Using live imaging of transcription, together with single cell transcriptomics and molecular genetics, we have addressed the biological implications of discontinuous transcription for symmetry-breaking in populations of cells during development.  We have also evaluated the reality of different models for the mechanisms of transcription bursting, using imaging approaches informed by the natural organisation of gene families within genomes.

 

Imprimer Envoyer

Université de Strasbourg
INSERM
CNRS

IGBMC - CNRS UMR 7104 - Inserm U 1258
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr