Molecular and cellular mechanisms regulating neural stem cell activity
Pr Sebastian JESSBERGER
Brain research institute, University of Zurich, Suisse
vendredi 25 janvier 2019 - 11h00
- Auditorium, IGBMC
Invité(e) par Biologie du développement et cellules souches, Sophie JARRIAULT, Julien VERMOT
Neural stem cells generate new neurons in distinct regions of the mammalian brain throughout life. This process, called adult neurogenesis, is critically involved in certain forms of learning and memory. In addition, failing or altered neurogenesis has been associated with a number of neuro-psychiatric diseases such as major depression and epilepsy. We aim to characterize the cellular and molecular mechanisms regulating neural stem cell activity and behavior. However, the mechanisms underlying life-long neurogenesis on a single cell level remain poorly understooddue to a lack of longitudinal observations of individual neural stem cells and their progeny within their endogenous niche. Here we present new approaches to study the cellular principles underlying neurogenesis within the endogenous adult hippocampal niche. Further, we provide evidence for novel molecular mechanisms governing the neurogenic process in the adult brain. Thus, the data presented provide new insights into the cellular principles of hippocampal neurogenesis and identify novel mechanisms regulating the behavior of rodent and human neural stem cells.