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Regulation of the mTORC1 pathway: from structure to function and back

Dr Svetlana DOKUDOVSKAYA
Institut Gustave Roussy, Villejuif, France

mardi 22 août 2017 - 14h30 - Salle de conférence E1031, CBI
Invité(e) par Biologie structurale intégrative, Marat YUSUPOV

The highly conserved mechanistic Target of Rapamycin Complex 1 (mTORC1) controls eukaryotic cell growth and response to a variety of signals, including nutrients, hormones and stresses. The pathways that convey upstream signals to mTORC1 are frequently deregulated by mutations in cancer and other diseases. The structural organization of the mTORC1 pathway components indicates that the mTORC1 network is an example of an evolutionary connection among the different complexes involved in the control of intracellular membrane trafficking systems. One of such examples is a novel upstream regulator of mTORC1, that we have recently identified – the multiprotein SEA/GATOR complex, which contains numerous structural elements present in intracellular structural trafficking complexes. I will provide an overview of the upstream regulation of the mTORC1 pathway, with a special attention to the structure and function of the SEA/GATOR in this process.

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