The intricate world of interorgan communication: A Drosophila perspective
Pr Norbert PERRIMON
Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Cambridge, États-Unis
mardi 09 mai 2017 - 11h00
- Auditorium, IGBMC
Invité(e) par Génomique fonctionnelle et cancer, Angela GIANGRANDE
Organ functions are highly specialized. For example, nutrients are taken up through the gut;sensed, processed, stored, and released by the liver and adipose tissues; and utilized by the peripheralorgans. Nutrients are used by the skeletal muscle and heart for contraction, by the brainfor behavior, by the kidney for water balance and waste disposal, by the gonads for reproduction,and by other tissues for growth. In addition, each organ depends on otherorgans. For instance, increased physiological demands such as exercise, brain activity, growth, and disease require increased nutrient uptake by the gut and nutrient release (sugars, fats, ketonebody) by the liver and adipose tissues. Because organ functions are interdependent, it is important to understand how organs communicate their states to each other, especially as it has implications to understand disease mechanisms and aging. Drosophila has emerged in recent years as a prime model to dissect the intricate interactions between organs and the role hormones play in coordinating the state of one organ/tissue with others. I will discuss our current studies on dissecting the interorgan communication network in Drosophila.