Shape and size control in planarian flatworms
Dr Jochen RINK
MPI of Molecular Cell Biology and Genetics, Allemagne
vendredi 24 mars 2017 - 11h00
- Auditorium, IGBMC
Invité(e) par Biologie du développement et cellules souches, Daniel RIVELINE
Planarians are amazing animals. Best known for their ability to regenerate complete and perfectly proportioned animals from arbitrary tissue pieces, they also do not have a fixed body size. They grow when fed and literally shrink when starving, continuously adjusting their body size between 0.5 mm and 20 mm in length or between 15 000 or 7 Millions of constituent cells. Abundant pluripotent stem cells are at the core of such astonishing body plan plasticity and their division progeny continuously replaces all organismal cell types and tissues. Our lab takes a interdisciplinary approach to understanding the molecular basis of shape and size. We investigate the self-organizing patterning systems that specify the body plan and the multi-scale regulation of body size. An increasingly important research direction is a large collection of wild planarian species that we have established, which allows us to examine shape and size also from a comparative perspective.